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What the reviews found

Supplements for Cholesterol & Triglycerides

33 where systematic reviews concluded a benefit, 15 with mixed findings, 9 where they concluded no effect, and 4 where harm was reported. Every line quotes the review and links it, so you can read the sentence yourself.

Reviews found a benefit

Systematic reviews concluded these improve an outcome tied to cholesterol & triglycerides, and none concluded no effect.

  1. Omega-3 (fish oil, EPA, DHA)
    11 reviews cited · harm also reported, see below
    Top-scored productThorne Super EPA
    92
    Find on Amazon
    Benefittriglycerides(as Omega-3)
    “Meta-analysis of 12 randomized controlled trials (474 participants) showed that omega-3 supplementation significantly reduced triglycerides (mean difference [MD] = -0.27 mmol/L, 95% CI: -0.35 to -0.20, p < 0.00001), systolic blood pressure (MD = -4.50 mmHg, 95% CI: -7.57 to -1.42, p = 0.004), and kidney injury molecule-1 (MD = -1.74 pg/mL, 95% CI: -2.58 to -0.89, p < 0.0001), while increasing high-density lipoprotein cholesterol (MD = 0.14 mmol/L, 95% CI: 0.04-0.23, p = 0.004).” PMID 42517346
    Benefithdl cholesterol(as Omega-3)
    “increasing high-density lipoprotein cholesterol (MD = 0.14 mmol/L, 95% CI: 0.04-0.23, p = 0.004)” PMID 42517346
    Benefitserum triglycerides(as Eicosapentaenoic Acid)
    “Moderate- and low-certainty evidence suggests that increasing LCn3 slightly reduces risk of coronary heart disease mortality and events, and reduces serum triglycerides (evidence mainly from supplement trials).” PMID 32114706

    9 more review findings point the same way — see Omega-3 (fish oil, EPA, DHA).

  2. Bergamot
    4 reviews cited
    Benefitldl cholesterol
    “The most effective approaches in terms of LDL-C- and TC-lowering were bergamot and RYR (-1.21 [-46.8 mg/dl] and -0.94 [-36.4 mg/dl] mmol/l) reduction respectively.” PMID 35988871 · 3 reviews
    Benefittotal cholesterol
    “The decrease in total cholesterol varied from 12.3% to 31.3%” PMID 31670973 · 3 reviews
    Benefittriglycerides
    “from 11.5% to 39.5% in triglycerides.” PMID 31670973 · 2 reviews
  3. Chlorogenic Acid
    3 reviews cited
    Benefittriglycerides
    “triglyceride levels (WMD = -0.27; 95% CI: -0.43, -0.10)” PMID 34577880
    Benefithdl cholesterol
    “high-density lipoprotein-cholesterol levels (WMD = 0.62; 95% CI: 0.34, 0.90)” PMID 34577880
    Benefittotal cholesterol
    “we found that GCE supplementation improved FBG and serum levels of insulin and TC.” PMID 32665012
  4. Artichoke
    2 reviews cited
    Top-scored productBulkSupplements Artichoke Extract Capsules
    92
    Find on Amazon
    Benefittotal cholesterol
    “a significant decrease in plasma concentrations of total cholesterol (WMD: -17.6 mg/dL, 95%CI: -22.0, -13.3, p < 0.001)” PMID 28609140
    Benefitldl cholesterol
    “Low Density Lipoprotein-Cholesterol (LDL-C; WMD: -14.9 mg/dL, 95%CI: -20.4, -9.5, p = 0.011)” PMID 28609140
    Benefittriglycerides
    “triglycerides (WMD: -9.2 mg/dL, 95%CI: -16.2, -2.1, p = 0.011)” PMID 28609140
  5. Astaxanthin
    1 review cited
    Top-scored productPure Encapsulations Astaxanthin
    93
    Find on Amazon
    Benefithdl cholesterol
    “astaxanthin: 0.13 [0.05, 0.21] mmol/L)” PMID 39064656
    Benefittotal cholesterol
    “astaxanthin: -0.22 [-0.32, -0.12] mmol/L” PMID 39064656
    Benefittriglycerides
    “astaxanthin: -0.46 [-0.83, -0.10] mmol/L” PMID 39064656
  6. Anthocyanins
    2 reviews cited
    Benefitldl cholesterol
    “Supplementation with anthocyanins significantly improved LDL cholesterol among diseased individuals or those with elevated biomarkers.” PMID 26761031
    Benefithdl cholesterol and triglycerides
    “Dietary anthocyanins effectively improve low HDL cholesterol, hypertriglyceridemia, and hyperglycemia, making them a promising adjunct for managing MetS.” PMID 39928643
  7. Gymnema
    2 reviews cited
    Top-scored productBulkSupplements Gymnema Extract Powder
    90
    Find on Amazon
    Benefittriglycerides
    “our study also found that GS significantly reduces triglycerides (SMD 1.81 mg/dl, 95% CI 2.95 to -0.66, p < .0001, I2 : 96%), and total cholesterol (SMD 4.10 mg/dl, 95% CI 7.21 to -0.99, p < .0001, I2 : 98%) compared to baseline.” PMID 34467577 · 2 reviews
    Benefittotal cholesterol
    “GS supplementation significantly decreased triglyceride (p < .001), total cholesterol (p < .001), low-density lipoprotein (p < .001), fasting blood sugar (p < .001), and diastolic blood pressure (p = .003).” PMID 36580574 · 2 reviews
  8. Piperine
    2 reviews cited
    Benefittotal cholesterol
    “curcumin plus piperine significantly decreased total cholesterol and LDL-C in patients suffering from metabolic syndrome.” PMID 36649934 · 2 reviews
    Benefithdl cholesterol
    “increased high-density lipoprotein cholesterol (HDL-C) (WMD: 1.51 mg/mL, 95% CI: 0.29, 2.72, p = 0.015)” PMID 41057035
  9. Algal Oil
    1 review cited · harm also reported, see below
    Benefittriglycerides
    “The pooled estimate for the change in TG concentration was -0.20 mmol/L (95% CI: -0.27 to -0.14), 0.23 mmol/L (95% CI: 0.16-0.30) for LDL-C, and 0.07 mmol/L (95% CI: 0.05-0.10) for HDL-C.” PMID 22113870
    Benefithdl cholesterol
    “DHA supplementation from algal oil, a marine source of (n-3) fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease.” PMID 22113870
  10. Hydroxytyrosol
    1 review cited
    Benefittotal cholesterol
    “significantly reduced total cholesterol (SMD = -0.19, CI: -0.37 to -0.01, p = 0.04, I2 = 35%)” PMID 39828996
    Benefittriglycerides
    “triacylglycerol (SMD = -0.32, CI: -0.60 to -0.03, p = 0.03, I2 = 73%)” PMID 39828996
  11. Magnesium
    1 review cited
    Top-scored productThorne Magnesium Glycinate
    96
    Find on Amazon
    Benefittriglycerides
    “triglycerides (WMD: -9.24 mg/dL; 95% CI: -16.87, -1.61)” PMID 42588058
    Benefithdl cholesterol
    “High-density lipoprotein cholesterol concentrations significantly increased (WMD: 1.45 mg/dL; 95% CI: 0.37, 2.54).” PMID 42588058
  12. Omega 6 Fatty Acids
    1 review cited
    Benefitldl cholesterol
    “the combination of omega-3 fatty acids (n-3) and omega-6 fatty acids (n-6) produced significantly lower LDL (standardized mean difference (SMD) = -1.43, 95% confidence interval: -2.28 to -0.57) than the placebo.” PMID 35334907
    Benefithdl cholesterol
    “Both n-3 fatty acids (SMD = 0.78) and the combination of n-3 + n-6 (SMD = 1.09) benefited HDL significantly compared with placebo.” PMID 35334907
  13. Cinnamon
    3 reviews cited
    Benefitlipid profile
    “The current evidence shows that cinnamon can regulate lipid profiles in patients with metabolic disorders.” PMID 35803022 · 3 reviews
  14. Bilberry
    2 reviews cited
    Benefittriglycerides
    “Bilberry supplementation may have beneficial effects on HbA1c and TG, but not other cardio-metabolic indices.” PMID 40751398
  15. Ginger
    2 reviews cited
    Top-scored productNOW Foods Ginger Root
    89
    Find on Amazon
    Benefitlipid profile
    “TG (WMD = -11.98 mg/dL; 95% CI = -23.27, -0.69), LDL (WMD = -4.55 mg/dL; 95% CI = -8.43, -0.68), HDL (WMD = 0.80 mg/dL; 95% CI = 0.01, 1.59)” PMID 41195902 · 2 reviews
  16. Spirulina
    2 reviews cited
    Top-scored productNOW Foods Certified Organic Spirulina
    87
    Find on Amazon
    Benefitlipid profile
    “This meta-analysis showed a significant effect of supplementation with Spirulina in reducing plasma concentrations of total cholesterol, LDL-C, triglycerides and elevating those of HDL-C.” PMID 26433766 · 2 reviews
  17. Aloe Vera
    1 review cited
    Top-scored productNutricost Aloe Vera Capsules
    87
    Find on Amazon
    Benefitlipid profile
    “Aloe vera, Nigella sativa, and spirulina were associated with beneficial effects on both lipid profiles and glycemic control.” PMID 33724587
  18. Berberine
    1 review cited
    Top-scored productThorne Berberine
    96
    Find on Amazon
    Benefitlipid profile
    “Meta-analysis of the data suggested that dietary supplementation with Armolipid Plus® exerted a significant effect on body mass index (mean difference (MD) = -0.25 kg/m2, p = 0.008) and serum levels of total cholesterol (MD = -25.07 mg/dL, p < 0.001), triglycerides (MD = -11.47 mg/dL, p < 0.001), high-density lipoprotein cholesterol (MD = 1.84 mg/dL, p < 0.001), low-density lipoprotein cholesterol (MD = -26.67 mg/dL, p < 0.001), high sensitivity C reactive protein (hs-CRP, MD = -0.61 mg/L, p = 0.022), and fasting glucose (MD = -3.52 mg/dL, p < 0.001).” PMID 33669333
  19. Black Pepper
    1 review cited
    Benefitblood lipids
    “hypolipidemic activity as evidenced by decrease in the level of cholesterol, triglycerides, and low-density lipoprotein and increase in high-density lipoprotein” PMID 30740986
  20. Blueberry
    1 review cited
    Top-scored productBulkSupplements Blueberry Extract Capsules
    87
    Find on Amazon
    Benefitlipid profile
    “Meta-analyses of the data showed that blueberry intervention had a significant effect on lipid levels, decreasing total cholesterol and low-density lipoprotein (LDL) levels.” PMID 34139510
  21. Bromelain
    1 review cited
    Top-scored productPure Encapsulations Bromelain 2400
    86
    Find on Amazon
    Benefitglycemic and lipid indices
    “Bromelain supplementation is effective in improving glycemic and lipid indices in diabetes.” PMID 40440445
  22. Chicory
    1 review cited
    Top-scored productNutricost Chicory Root Capsules
    90
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    Benefitlipid profile
    “This meta-analysis showed that chicory supplementation may exert potential hepatoprotective effects in patients with NAFLD.” PMID 37202083
  23. CoQ10
    1 review cited
    Top-scored productNootropics Depot CoQH-CF Softgels
    97
    Find on Amazon
    Benefitlipid metabolism
    “CoQ10 supplementation has beneficial effects on lipid metabolism, glycemic control, and inflammation among individuals with metabolic disorders.” PMID 42192187
  24. Grape Seed
    1 review cited
    Top-scored productThorne Grape Seed Extract
    92
    Find on Amazon
    Benefitldl and total cholesterol
    “intervention with bilberry and blackcurrant extract, and to some extent grape seed extract, significantly lowered total and low density lipoprotein (LDL) cholesterol levels after four weeks.” PMID 34067538
  25. Inositol
    1 review cited
    Top-scored productPure Encapsulations Inositol (powder)
    94
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    Benefitlipid profile
    “Chromium, inositol, and Omega-3 were found to be beneficial for improving lipid profile.” PMID 40611279
  26. Inulin
    1 review cited
    Top-scored productMegaFood Baby & Me 2 Prenatal Probiotic + Prebiotic
    88
    Find on Amazon
    Benefittriglycerides
    “Beneficial health effects reported following ITF intake include improved intestinal barrier function, improved laxation, increased insulin sensitivity, decreased triglycerides and an improved lipid profile, increased absorption of calcium and magnesium, and increased satiety.” PMID 34555168
  27. Lutein
    1 review cited
    Top-scored productPure Encapsulations Lutein/Zeaxanthin
    93
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    Benefithdl cholesterol
    “L/Z administration could be an effective treatment for improving circulating HDL-C concentration in elderly adults.” PMID 36336325
  28. Lycopene
    1 review cited
    Top-scored productPure Encapsulations Lycopene 20 mg
    91
    Find on Amazon
    Benefitblood lipids
    “The available evidence on the effects of tomato products and lycopene supplementation on CV risk factors supports the view that increasing the intake of these has positive effects on blood lipids, blood pressure and endothelial function.” PMID 28129549
  29. Niacin
    1 review cited
    Top-scored productNOW Foods Niacin
    92
    Find on Amazon
    Benefittriglycerides
    “Niacin supplements ranked best in triglyceride reductions and increasing high-density lipoprotein cholesterol levels with low to very low evidence certainty (SUCRAs:93.7% and 94.6%, respectively).” PMID 36638933
  30. Tart Cherry
    1 review cited
    Benefitlipid profile
    “Tart cherry supplementation did not have significant effects on anthropometric and glycemic indices, but can improve lipid profile, especially in a single dose, longer duration, and in elderly, obese, and unhealthy individuals.” PMID 38759306
  31. Vanadium
    1 review cited
    Benefittotal cholesterol
    “Vanadium supplements ranked best in lowering total cholesterol levels with very low evidence certainty (SUCRAs:100%).” PMID 36638933
  32. Watermelon
    1 review cited
    Benefittotal cholesterol
    “Watermelon consumption significantly decreased systolic blood pressure (SBP), totalcholesterol (TC) and low-density lipoprotein (LDL).” PMID 37369281
  33. Zeaxanthin
    1 review cited
    Top-scored productPure Encapsulations Lutein/Zeaxanthin
    93
    Find on Amazon
    Benefithdl cholesterol
    “L/Z administration could be an effective treatment for improving circulating HDL-C concentration in elderly adults.” PMID 36336325

Mixed: a benefit on one measure, no effect on another

  1. Beta-Glucan
    4 reviews cited
    Benefitldl cholesterol
    “oat beta-glucan supplementation significantly reduced levels of TC (pooled WMD = -0.24 mmol/L; 95%CI: -0.28 to -0.20 mmol/L), LDL-c (pooled WMD = -0.27 mmol/L; 95%CI: -0.35 to -0.20 mmol/L).” PMID 35631184 · 4 reviews
    No effecttriglycerides
    “beta-glucan consumption did not show significant effects on TG (pooled WMD = -0.04 mmol/L; 95%CI: -0.13 to 0.05 mmol/L), HDL-c (pooled WMD = 0.00 mmol/L; 95%CI: -0.05 to 0.05 mmol/L).” PMID 35631184
    Benefitnon-hdl cholesterol
    “Pooled analyses show that barley β-glucan has a lowering effect on LDL-C and non-HDL-C.” PMID 27273067 · 2 reviews

    1 more review finding.

  2. Lignans
    3 reviews cited
    Benefitldl cholesterol
    “low-density lipoprotein cholesterol (LDL-C) (WMD = -4.206 mg/dl; 95% CI: -7.260, -1.151, p = 0.007) concentrations.” PMID 31899314 · 2 reviews
    Benefittotal cholesterol
    “flaxseed supplementation significantly reduced total cholesterol (TC) (WMD = -5.389 mg/dL; 95% CI: -9.483, -1.295, p = 0.010)” PMID 31899314 · 2 reviews
    Benefittriglycerides
    “triglyceride (TG) (WMD = -9.422 mg/dL; 95% CI: -15.514, -3.330, p = 0.002)” PMID 31899314

    1 more review finding.

  3. Melatonin
    1 review cited
    Top-scored productPure Encapsulations Melatonin 3 mg
    92
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    Benefitldl cholesterol
    “low-density lipoprotein cholesterol (WMD: -6.28 mg/dL, 95% CI: -10.53, -2.03)” PMID 41515249
    Benefittotal cholesterol
    “total cholesterol (WMD: -6.97 mg/dL, 95% CI: -12.20, -1.74)” PMID 41515249
    Benefithdl cholesterol
    “high-density lipoprotein cholesterol (WMD: 2.04 mg/dL, 95% CI: 0.50, 3.57)” PMID 41515249

    1 more review finding — see Melatonin.

  4. Red Yeast Rice
    9 reviews cited
    Top-scored productThorne Red Yeast Rice
    92
    Find on Amazon
    Benefittotal cholesterol
    “RYR extract consumption statistically significantly reduced total cholesterol (mean absolute reduction: 37.43 mg/dL; 95% confidence interval [CI]: -47.08, -27.79) and low-density lipoprotein cholesterol (LDL-C; mean absolute reduction: 35.82 mg/dL; 95% CI: -43.36, -28.29), but not high-density lipoprotein cholesterol, triglycerides and apolipoproteins A-I and B.” PMID 38794691 · 8 reviews
    Benefitldl cholesterol
    “RYR exerts a clinically and statistically significant reduction of 1.02 mmol/L LDL cholesterol.” PMID 25897793 · 8 reviews
    No effectapolipoproteins
    “but not high-density lipoprotein cholesterol, triglycerides and apolipoproteins A-I and B.” PMID 38794691
  5. Plant Sterols
    6 reviews cited
    Top-scored productNOW Foods Beta-Sitosterol Plant Sterols
    79
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    Benefitldl cholesterol
    “Intake of plant sterol/stanol supplements decreased LDL-cholesterol concentrations by 12 mg/dL (0.31 mmol/L) (95% CI -0.39 to -0.23; P<0.000) compared with placebo.” PMID 24144075 · 6 reviews
    Benefittotal cholesterol
    “moderate reductions in LDL-C and total cholesterol” PMID 42275989 · 2 reviews
    No effecttriglycerides
    “trivial improvements in triglycerides, apoA-I, apoB/A-I, apoE, Lp(a), FFA, blood pressure, and BMI” PMID 42275989
  6. Olive Oil
    3 reviews cited
    No effectglycemic and lipid markers
    “pooled analyses demonstrated no statistically or clinically significant effects on glycemic or lipid outcomes” PMID 41848522
    No effectserum lipids
    “Evidence indicates no significant difference in serum lipid profile and DBP between the MED diet supplemented with olive oil and that with mixed nuts in participants at risk of CVD.” PMID 40651889
    Benefittotal cholesterol
    “significantly reduced total cholesterol (SMD = -0.19, CI: -0.37 to -0.01, p = 0.04, I2 = 35%)” PMID 39828996

    1 more review finding.

  7. Moringa
    2 reviews cited
    Top-scored productDouble Wood Moringa Supplement
    88
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    No effectcardiometabolic outcomes (lipids/anthropometrics)
    “Moringa supplementation showed no significant effects on most considered outcomes.” PMID 41305552
    Benefitcholesterol levels
    “control of cholesterol levels.” PMID 38015892
    Benefitcholesterol levels(as Moringa oleifera)
    “moringa supplementation resulted to increases in CD4 cell count and body mass index, improvements in psychological well-being, in management of depression and anxiety and the function of vital body organs and control of cholesterol levels.” PMID 38015892
  8. Bitter Melon
    1 review cited
    Top-scored productBulkSupplements Bitter Melon Extract Powder
    87
    Find on Amazon
    Benefittotal cholesterol
    “Bitter melon consumption resulted in a significant decrease in plasma concentrations of TC (WMD; -9.71 mg/dL; CI: -17.69 to -1.74, p = 0.01)” PMID 39444254
    Benefittriglycerides
    “TG (WMD; -10.24 mg/dL; CI: -19.92 to -0.56, p = 0.03)” PMID 39444254
    No effectldl cholesterol
    “bitter melon did not significantly lower blood LDL-C (WMD; -8.66 mg/dL; CI: -19.83 to 2.50, p = 0.12)” PMID 39444254

    1 more review finding — see Bitter Melon.

  9. Resveratrol
    3 reviews cited
    Top-scored productPure Encapsulations Resveratrol
    90
    Find on Amazon
    No effectglycemic indices and lipid profile in type 2 diabetes
    “resveratrol supplementation was not considered as a beneficial agent in declining glycemic indices and lipid profile in patients with T2DM.” PMID 42268476
    Benefittotal cholesterol
    “reduce total cholesterol among overweight adults.” PMID 41987155
  10. Curcumin
    2 reviews cited
    Top-scored productPure Encapsulations Curcumin
    90
    Find on Amazon
    Benefittriglycerides
    “Curcumin supplementation was associated with decreases in body weight (up to 0.82 kg), BMI (up to 0.30 kg/m2), triglycerides, total cholesterol, and fasting glucose levels.” PMID 42280140
    No effectlipid profile in type 2 diabetes
    “Current evidence suggests that short-term nanocurcumin supplementation does not significantly improve glycemic control, lipid profile or systemic inflammation in patients with T2DM.” PMID 42171191
  11. Oleuropein
    2 reviews cited
    No effectlipid outcomes
    “pooled analyses demonstrated no statistically or clinically significant effects on glycemic or lipid outcomes” PMID 41848522
    Benefittotal cholesterol
    “OLE, HT, and TYR significantly reduced total cholesterol (SMD = -0.19, CI: -0.37 to -0.01, p = 0.04, I2 = 35%)” PMID 39828996
  12. Pomegranate
    2 reviews cited
    Top-scored productLife Extension Pomegranate Fruit Extract
    84
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    Benefithdl cholesterol
    “pomegranate intake significantly increased HDL-C levels (mean difference: 2.50 mg/dL, 95 % CI: 1.00-4.00, p < 0.05)” PMID 40216355 · 2 reviews
    No effectldl cholesterol
    “no significant changes were observed in TC, LDL-C, or TG.” PMID 40216355
  13. Pycnogenol
    2 reviews cited
    Top-scored productLife Extension Pycnogenol French Maritime Pine Bark Extract
    92
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    Benefithdl cholesterol
    “a significant increase in plasma concentration of high density lipoprotein cholesterol (HDL-C; 3.27 mg/dL; 95% CI [0.19, 6.36]; p = 0.038).” PMID 30456865
    No effectldl cholesterol
    “low density lipoprotein cholesterol (LDL-C; -3.61 mg/dl; 95% CI [-8.76, 1.55]; p = 0.171) were not altered.” PMID 30456865
    No effecttriglycerides
    “triacylglycerol (TAG; -3.64 mg/dL; 95% CI [-17.89, 10.61]; p = 0.616), and low density lipoprotein cholesterol (LDL-C; -3.61 mg/dl; 95% CI [-8.76, 1.55]; p = 0.171) were not altered.” PMID 30456865

    1 more review finding — see Pycnogenol.

  14. Melissa officinalis
    1 review cited
    Benefittotal cholesterol
    “MO intake was associated with a reduced total cholesterol (TC) (SMD: -0.26; 95% CI: -0.52, -0.01; I2 = 13.7%; k = 6)” PMID 32614129
    No effecttriglycerides
    “MO intake was not associated with statistically significant changes in triglycerides, low-density lipoprotein, diastolic blood pressure, high sensitivity c-reactive protein levels, fasting blood sugar, HbA1c, insulin or high-density lipoprotein levels.” PMID 32614129
  15. Vitamin D
    1 review cited
    Top-scored productMomentous Vegan Vitamin D3 5000 IU Supplement
    95
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    Benefittriglycerides(as Cholecalciferol)
    “vitamin D has a significant effect on hypertriglyceridemia in individuals who are overweight or obese” PMID 39873663
    No effectldl cholesterol(as Cholecalciferol)
    “vitamin D has no significant effect on LDL-C concentrations in this population” PMID 39873663

Reviews found no effect

Reviews studied these for an outcome tied to cholesterol & triglycerides and concluded they made no difference.

  1. Alpha Lipoic Acid
    1 review cited
    Top-scored productNOW Foods Alpha Lipoic Acid
    88
    Find on Amazon
    No effectnafld markers (liver enzymes, lipids, glycemic indices, obesity)
    “ALA supplementation did not improve liver enzymes, lipid profiles, glycemic indices, adipocytokines, and obesity measures in patients with NAFLD.” PMID 41917882
  2. Betaine
    2 reviews cited · harm also reported, see below
    Top-scored productNutricost TMG Capsules
    92
    Find on Amazon
    No effecthdl cholesterol
    “No significant effect was observed for LDL, HDL, or TG.” PMID 31809615
  3. Capsicum
    3 reviews cited
    Top-scored productNutricost Cayenne Pepper Capsules
    86
    Find on Amazon
    No effecthdl cholesterol
    “did not regulate triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol concentrations” PMID 37344950
  4. Chlorella
    2 reviews cited
    Top-scored productNOW Foods Certified Organic Chlorella
    87
    Find on Amazon
    No effecttriglycerides
    “We found that Chlorella vulgaris supplementation had a beneficial effect on TC and LDL-C levels with no significant effect on TG and HDL-C levels.” PMID 35331862
  5. DHEA
    1 review cited · harm also reported, see below
    Top-scored productPure Encapsulations DHEA 5 mg
    92
    Find on Amazon
    No effectlipid profile (tc, ldl-c, tg)
    “Overall, supplementation with DHEA did not change circulating values of TC, LDL-C and TG, whereas it may decrease HDL-C levels.” PMID 32675010
  6. Nicotinamide Mononucleotide
    1 review cited
    Top-scored productProHealth Longevity NMN Pro 1000™
    86
    Find on Amazon
    No effectglucose and lipid metabolism markers
    “The random-effects meta-analyses indicated no significant benefit of NMN on fasting glucose, fasting insulin, glycated hemoglobin, homeostatic model assessment for insulin resistance and lipid profile.” PMID 39531138
  7. Selenium
    2 reviews cited
    Top-scored productThorne Selenium
    96
    Find on Amazon
    No effecttotal cholesterol
    “it does not significantly affect total cholesterol, triglycerides, low density lipoprotein cholesterol, or high density lipoprotein cholesterol levels” PMID 41073938 · 2 reviews
  8. Vitamin E
    1 review cited
    Top-scored productNutricost Vitamin E Softgels
    88
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    No effectblood lipids
    “However, their effects on glycemic control, diastolic blood pressure, and blood lipids other than HDL were comparable.” PMID 41521729
  9. Vitamin K2
    1 review cited
    Top-scored productJarrow Formulas MK-7 - 90mcg
    95
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    No effectlipid profile and other cardiovascular risk factors
    “We demonstrated that supplementation with vitamin K has no effect on anthropometrics indexes, CRP, glucose metabolism, and lipid profile factors except HOMA-IR.” PMID 38282652

Harm reported

  1. Algal Oil
    1 review cited
    Harm reportedldl cholesterol
    “DHA supplementation from algal oil, a marine source of (n-3) fatty acids not extracted from fish, may reduce serum TG and increase HDL-C and LDL-C in persons without coronary heart disease.” PMID 22113870
  2. Betaine
    2 reviews cited
    Top-scored productNutricost TMG Capsules
    92
    Find on Amazon
    Harm reportedtotal cholesterol
    “Supplementation with at least 4 g/d of betaine for a minimum of six weeks may moderately increase plasma TC, which might be important in the context of cardiovascular health.” PMID 31809615
  3. DHEA
    1 review cited
    Top-scored productPure Encapsulations DHEA 5 mg
    92
    Find on Amazon
    Harm reportedhdl cholesterol
    “Overall, supplementation with DHEA did not change circulating values of TC, LDL-C and TG, whereas it may decrease HDL-C levels.” PMID 32675010
  4. Omega-3 (fish oil, EPA, DHA)
    11 reviews cited
    Top-scored productThorne Super EPA
    92
    Find on Amazon
    Harm reportedldl cholesterol(as Docosahexaenoic Acid as TG)
    “dietary EPA/DHA supplementation improved the TG and HDL status but increased LDL levels in comparison with ALA” PMID 32175534 · 2 reviews
    Harm reportedtotal cholesterol(as Docosahexaenoic Acid as TG)
    “total cholesterol (TC) (WMD 0.179 mmol l-1; 95% CI 0.006, 0.352)” PMID 32175534
    Harm reportedldl cholesterol(as Eicosapentaenoic Acid as TG)
    “low-density lipoprotein (LDL) (WMD 0.130 mmol l-1; 95% CI 0.006, 0.253)” PMID 32175534 · 2 reviews

    1 more review finding points the same way — see Omega-3 (fish oil, EPA, DHA).

Not enough to say

Reviews of Chromium, Lactobacillus plantarum, Mango, Phosphorus, Rice Bran could not conclude either way on cholesterol & triglycerides.

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How this page is built

Each finding is the conclusion a set of systematic reviews reached on one outcome — whether an ingredient helped, made no difference, or could not be judged — with a sentence quoted from one review, checked to appear in its PubMed abstract. It records the direction, not the size, of an effect. Reviews run in populations such as people with cancer, pregnancy, surgery or children are left out, because applying them to a general reader would mislead. Evidence last refreshed September 2026. Abstracts courtesy of the U.S. National Library of Medicine (PubMed). The full report explains how the conclusions were read and checked.

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Educational only. A review finding a benefit on average does not mean a supplement will help you, or that it is safe alongside your medication. If you are treated for cholesterol & triglycerides, talk to your clinician before adding anything.