Antioxidant
Alpha-Lipoic Acid (ALA)
Also known as: ALA, Lipoic acid, Thioctic acid, Alpha-Lipoic Acid
A
Evidence
Universal antioxidant working in both water and fat. Regenerates other antioxidants and supports blood sugar metabolism.
Primary uses
- Antioxidant
- Blood sugar support
- Neuropathy
- Heavy metal chelation
- Detoxification
- Blood sugar
- Nerve health
- Insulin sensitivity
How it works
- Works in water and fat compartments
- Regenerates vitamins C and E
- Enhances insulin sensitivity
- Chelates heavy metals
Dosage
- Typical range
- 300-600 mg daily (150-300 R-ALA)
- Timing
- Empty stomach for blood sugar; any for antioxidant
- With food
- Empty stomach better absorbed
- Duration
- Safe long-term
- Special populations
- Diabetics, neuropathy
Forms
- R-ALA
- Racemic ALA
- Na-R-ALA
- R-lipoic acid
- Alpha-lipoic acid
Safety
Common side effects
- Hypoglycemia
- Skin rash
- GI upset
Contraindications
- Thiamine deficiency (deplete)
Evidence notes
Well-studied for neuropathy and blood sugar
Grade A: Multiple well-designed human trials support the main claims.
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