Antioxidant
Glutathione
Also known as: GSH, L-glutathione, Reduced glutathione
Master antioxidant for detoxification. Liposomal or acetyl forms needed for oral absorption.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Glutathione product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne SynaQuell +™ | 88 A | $1.47 |
| 2 | Thorne Glutathione-SR | 86 A- | $0.90 |
| 3 | Thorne MediClear-SGS™ - Vanilla | 86 A- | $2.10 |
| 4 | Pure Encapsulations Reduced Glutathione | 86 A- | $0.49 |
| 5 | Jarrow Formulas Glutathione Reduced | 86 A- | $0.67 |
| 6 | Nutricost Glutathione Capsules | 86 A- | $0.18 |
| 7 | Double Wood Liposomal Glutathione Supplement | 86 A- | $1.00 |
| 8 | Nordic Naturals Omega Curcumin | 82 A- | $1.50 |
| 9 | BioSchwartz Glutathione Complex Capsules | 82 A- | $0.80 |
| 10 | NOW Foods Clinical Strength Ocu Support | 81 A- | $0.73 |
| 11 | Thorne Daily Greens Plus | 79 B+ | $0.83 |
| 12 | Vital Nutrients Glutathione 400mg | 79 B+ | $1.66 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Glutathione should I take?
The typical range is 250-1000 mg daily (liposomal or acetyl form). Safe long-term
When should I take Glutathione?
Empty stomach. Empty stomach.
Which form of Glutathione is best?
Liposomal — Best oral absorption. Other forms in the catalog: S-acetyl glutathione, Reduced (standard).
Is Glutathione safe?
Commonly reported: Well tolerated. Serious warnings: None. Supports liver
Which Glutathione supplement scores highest?
Thorne SynaQuell +™, at 88/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Antioxidant
- Detoxification
- Immune support
- Skin lightening
What systematic reviews concluded
Outcomes that systematic reviews of Glutathione reached a verdict on: 1 with a benefit, 1 with no effect. Each is quoted from a review and linked to it on PubMed. How these were read.
Reviews found a benefit (1)
“Topical versus oral glutathione both provide moderately efficacious skin-lightening outcomes that are localized versus generalized and have minimal versus substantial adverse effects, but they are unsustainable, with variable costs.” PMID 39444151
Reviews found no effect (1)
“IV glutathione is contraindicated due to lack of efficacy and side effects.” PMID 39444151
How it works
- Phase II detoxification
- Neutralizes free radicals
- Immune cell function
- Regenerated by NAC
Dosage
- Typical range
- 250-1000 mg daily (liposomal or acetyl form)
- Timing
- Empty stomach
- With food
- Empty stomach
- Duration
- Safe long-term
- Special populations
- Detox, immune support, skin
Forms
- Liposomal
- S-acetyl glutathione
- Reduced (standard)
Safety
Common side effects
- Well tolerated
Contraindications
- None
Products containing Glutathione
Top-scoring supplements in our catalog that list Glutathione on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Known interactions
Evidence notes
Master antioxidant; absorption form-dependent
Grade B: Some human trials support key claims; further confirmation needed.
Cited research for Glutathione
Clinical studies referenced across Formulate guides that mention glutathione. Each links to the full study page with PubMed source + the guides that cite it.
Glutathione compared head-to-head
Related in Antioxidant
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.