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glutathione and nac

NAC is the rate-limiting precursor to glutathione

What's happening

N-acetylcysteine supplies the cysteine needed to synthesize glutathione, the body's primary intracellular antioxidant. Oral glutathione has poor bioavailability, so raising glutathione via NAC is usually more effective.

Recommendation

600-1200mg NAC daily is typically more effective than oral glutathione for raising cellular glutathione levels.

Timing

Take NAC on an empty stomach

Sources

  • Biochimica et Biophysica Acta
  • PMID: 23747562

Frequently Asked Questions

Can I take glutathione and nac together?

NAC is the rate-limiting precursor to glutathione. 600-1200mg NAC daily is typically more effective than oral glutathione for raising cellular glutathione levels.

How should I time glutathione and nac?

Take NAC on an empty stomach

Is this interaction dangerous?

This interaction is rated “Synergy” by Formulate. N-acetylcysteine supplies the cysteine needed to synthesize glutathione, the body's primary intracellular antioxidant. Oral glutathione has poor bioavailability, so raising glutathione via NAC is usually more effective.

Want to check your whole stack?

The free checker lets you add any combination of supplements and medications at once. Formulate's desktop app goes further — every stack change surfaces interaction alerts automatically.

Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.