NAC protects against acetaminophen liver damage
N-acetylcysteine (NAC) is the antidote for acetaminophen overdose. It replenishes glutathione, which protects the liver from NAPQI (toxic acetaminophen metabolite). Prophylactic NAC may offer protection with regular acetaminophen use.
NAC may be protective for regular acetaminophen users. Excellent safety profile.
Can take together; NAC is hepatoprotective
NAC protects against acetaminophen liver damage. NAC may be protective for regular acetaminophen users. Excellent safety profile.
Can take together; NAC is hepatoprotective
This interaction is rated “Synergy” by Formulate. N-acetylcysteine (NAC) is the antidote for acetaminophen overdose. It replenishes glutathione, which protects the liver from NAPQI (toxic acetaminophen metabolite). Prophylactic NAC may offer protection with regular acetaminophen use.
Studies from our registry that mention acetaminophen or nac. Each links to the primary source and the other Formulate pages citing it.
Mentions nac · 2011
N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action
Dean O, Giorlando F, Berk M · Journal of Psychiatry and Neuroscience
Reviews evidence for NAC as an adjunctive psychiatric treatment, with strongest data in trichotillomania, OCD, addictive behaviors, and as a glutathione precursor for oxidative stress reduction.
Mentions nac · 2008
Effectiveness of N-acetylcysteine in the prevention of contrast-induced nephropathy: a systematic review and meta-analysis
Kelly AM, Dwamena B, Cronin P, et al. · Annals of Internal Medicine
Meta-analysis of 41 trials found NAC associated with reduced risk of contrast-induced nephropathy, supporting clinical use of NAC for renal protection in high-risk patients undergoing contrast imaging.
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Other interactions to know
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Medical disclaimer. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.
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