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Antioxidant

CoQ10 (Ubiquinone/Ubiquinol)

Also known as: Coenzyme Q10, Ubiquinone, Ubiquinol, CoQ10

A
Evidence

Ubiquinol is the reduced, active form of CoQ10 that plays a critical role in cellular energy production via the mitochondrial electron transport chain and serves as a lipid-soluble antioxidant. It is more bioavailable than standard ubiquinone (oxidized CoQ10), particularly in aging populations.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Heart health
  • Energy
  • Statin support
  • Fertility
  • Energy production
  • Exercise capacity
  • Antioxidant
  • Blood pressure
  • Egg quality
  • Sperm quality
  • Mitochondrial function
  • Age-related fertility

How it works

  • Electron carrier in mitochondria
  • Lipid-soluble antioxidant
  • ATP production
  • Statins deplete CoQ10

Dosage

Typical range
100-300 mg daily
Timing
With fat-containing meal
With food
Yes, fat improves absorption
Duration
Safe long-term
Special populations
Statin users, heart patients, over 40

Forms

  • Ubiquinol
  • Ubiquinone
  • Ubiquinone (oxidized)· 70/100
  • Ubiquinol (reduced form)· 70/100
  • Softgel· 70/100
  • Capsule· 70/100
  • Liquid· 70/100

Safety

Common side effects

  • Well tolerated
  • Insomnia if late

Contraindications

  • None

Products containing CoQ10 (Ubiquinone/Ubiquinol)

Top-scoring supplements in our catalog that list CoQ10 (Ubiquinone/Ubiquinol) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Nootropics Depot
CoQH-CF Softgels
97
Thorne
Omega-3 with CoQ10
92
Thorne
CoQ10
90
Thorne
Heart Health Complex
89
See all products →

Evidence notes

Essential for energy and heart

Grade A: Multiple well-designed human trials support the main claims.

Cited research for CoQ10 (Ubiquinone/Ubiquinol)

Clinical studies referenced across Formulate guides that mention coq10 (ubiquinone/ubiquinol). Each links to the full study page with PubMed source + the guides that cite it.

CoQ10 (Ubiquinone/Ubiquinol) compared head-to-head

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.