Antioxidant
CoQ10 (Ubiquinone/Ubiquinol)
Also known as: Coenzyme Q10, Ubiquinone, Ubiquinol, CoQ10
Ubiquinol is the reduced, active form of CoQ10 that plays a critical role in cellular energy production via the mitochondrial electron transport chain and serves as a lipid-soluble antioxidant. It is more bioavailable than standard ubiquinone (oxidized CoQ10), particularly in aging populations.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every CoQ10 (Ubiquinone/Ubiquinol) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nootropics Depot CoQH-CF Softgels | 97 A | $1.00 |
| 2 | Pure Encapsulations Ubiquinol-QH 100 mg | 96 A | $1.65 |
| 3 | Pure Encapsulations Ubiquinol-QH 50 mg | 96 A | $1.06 |
| 4 | Pure Encapsulations Ubiquinol-QH 200 mg | 96 A | $2.87 |
| 5 | Jarrow Formulas QH-absorb - 200mg | 96 A | $1.44 |
| 6 | Jarrow Formulas QH-absorb - 100mg | 96 A | $0.85 |
| 7 | Life Extension Super Ubiquinol CoQ10 | 96 A | $0.63 |
| 8 | NOW Foods Ubiquinol | 95 A | $0.43 |
| 9 | NOW Foods Extra Strength Ubiquinol | 95 A | $0.93 |
| 10 | Jarrow Formulas QH-absorb + PQQ | 93 A | $1.42 |
| 11 | Thorne Omega-3 with CoQ10 | 92 A | $0.61 |
| 12 | Pure Encapsulations SR-CoQ10 with PQQ | 91 A | $3.13 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much CoQ10 (Ubiquinone/Ubiquinol) should I take?
The typical range is 100-300 mg daily. Safe long-term
When should I take CoQ10 (Ubiquinone/Ubiquinol)?
With fat-containing meal. Yes, fat improves absorption.
Which form of CoQ10 (Ubiquinone/Ubiquinol) is best?
Ubiquinol — Reduced, better absorbed. Other forms in the catalog: Ubiquinone, Ubiquinone (oxidized), Ubiquinol (reduced form), Softgel, Capsule, Liquid.
Is CoQ10 (Ubiquinone/Ubiquinol) safe?
Commonly reported: Well tolerated, Insomnia if late. Serious warnings: None. Safe
Which CoQ10 (Ubiquinone/Ubiquinol) supplement scores highest?
Nootropics Depot CoQH-CF Softgels, at 97/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Heart health
- Energy
- Statin support
- Fertility
- Exercise capacity
- Antioxidant
- Blood pressure
- Egg quality
- Sperm quality
- Mitochondrial function
What systematic reviews concluded
Outcomes that systematic reviews of CoQ10 (Ubiquinone/Ubiquinol) reached a verdict on: 4 with a benefit, 1 with no effect, 4 unclear. Each is quoted from a review and linked to it on PubMed. How these were read.
Reviews found a benefit (4)
“Overall, the results demonstrated that CoQ10 supplementation may improve several cardiovascular risk factors in patients with prediabetes and T2DM.” PMID 42642774
“CoQ10 supplementation has beneficial effects on lipid metabolism, glycemic control, and inflammation among individuals with metabolic disorders.” PMID 42192187
“Supplementation of CoQ10 can reduce muscle pain in patients with SAMS, which is relevant for their well-being and treatment continuation.” PMID 41158831
“CoQ10 was the most effective intervention measure for improving sperm concentration, and L-carnitine was regarded as the best treatment method for enhancing sperm motility.” PMID 40813743
Reviews found no effect (1)
“CoQ10 had no effect on the miscarriage rate.” PMID 41483781
Not enough to say: glycemic control; depressive symptoms; fatigue; anxiety.
3 findings from reviews in specific patient groups (such as cancer, pregnancy or surgery) are not shown here.
How it works
- Electron carrier in mitochondria
- Lipid-soluble antioxidant
- ATP production
- Statins deplete CoQ10
Dosage
- Typical range
- 100-300 mg daily
- Timing
- With fat-containing meal
- With food
- Yes, fat improves absorption
- Duration
- Safe long-term
- Special populations
- Statin users, heart patients, over 40
Forms
- Ubiquinol
- Ubiquinone
- Softgel· 70/100
- Capsule· 70/100
- Liquid· 70/100
Safety
Common side effects
- Well tolerated
- Insomnia if late
Contraindications
- None
Products containing CoQ10 (Ubiquinone/Ubiquinol)
Top-scoring supplements in our catalog that list CoQ10 (Ubiquinone/Ubiquinol) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Essential for energy and heart
Grade A: Multiple well-designed human trials support the main claims.
Cited research for CoQ10 (Ubiquinone/Ubiquinol)
Clinical studies referenced across Formulate guides that mention coq10 (ubiquinone/ubiquinol). Each links to the full study page with PubMed source + the guides that cite it.
- Mortensen SA, Rosenfeldt F, Kumar A, et al. (2014)JACC: Heart Failure
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure (Q-SYMBIO trial)
- Madmani ME, Yusuf Solaiman A, Tamr Agha K, et al. (2014)Cochrane Database of Systematic Reviews
Coenzyme Q10 for heart failure (Cochrane Review)
CoQ10 (Ubiquinone/Ubiquinol) compared head-to-head
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.