Antioxidant
Muscadine Grape Seed and Skin Powder
Also known as: Muscadine Grape Extract, Vitis rotundifolia, Muscadine Proanthocyanidins
Muscadine grape (Vitis rotundifolia) seed and skin powder is rich in proanthocyanidins, resveratrol, and other polyphenols with antioxidant and anti-inflammatory properties. Muscadine varieties are native to the southeastern United States and contain higher antioxidant concentrations than European grape varieties.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Common questions
How much Muscadine Grape Seed and Skin Powder should I take?
The typical range is 150-400 mg daily. Safe for long-term use
When should I take Muscadine Grape Seed and Skin Powder?
With meals. Recommended; fat-soluble polyphenols benefit from dietary fat context.
Which form of Muscadine Grape Seed and Skin Powder is best?
Seed and Skin Powder.
Is Muscadine Grape Seed and Skin Powder safe?
Commonly reported: Minimal, Mild headache or nausea possible at high doses.
Which Muscadine Grape Seed and Skin Powder supplement scores highest?
Codeage Multivitamin Performance Elite Max, at 76/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Antioxidant support
- Cardiovascular health
- Endothelial function
- Anti-inflammatory support
- Polyphenol intake
How it works
- Proanthocyanidin antioxidant activity
- Polyphenol-mediated oxidative stress reduction
- Anti-inflammatory signaling
- Vascular endothelial nitric oxide support
Dosage
- Typical range
- 150-400 mg daily
- Timing
- With meals
- With food
- Recommended; fat-soluble polyphenols benefit from dietary fat context
- Duration
- Safe for long-term use
- Special populations
- Bleeding disorders or anticoagulant use: caution with high doses; pregnancy/nursing: use food-level amounts
Forms
- Seed and Skin Powder· 70/100
Safety
Common side effects
- Minimal
- Mild headache or nausea possible at high doses
Contraindications
- Grape allergies
Products containing Muscadine Grape Seed and Skin Powder
Top-scoring supplements in our catalog that list Muscadine Grape Seed and Skin Powder on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Grape seed/skin extracts have moderate evidence for cardiovascular and antioxidant benefits. Muscadine-specific human clinical data is more limited than for European grape extracts, warranting a more conservative grade.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Antioxidant
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.