Antioxidant
Muscadine Grape Seed and Skin Powder
Also known as: Muscadine Grape Extract, Vitis rotundifolia, Muscadine Proanthocyanidins
Muscadine grape (Vitis rotundifolia) seed and skin powder is rich in proanthocyanidins, resveratrol, and other polyphenols with antioxidant and anti-inflammatory properties. Muscadine varieties are native to the southeastern United States and contain higher antioxidant concentrations than European grape varieties.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Antioxidant support
- Cardiovascular health
- Endothelial function
- Anti-inflammatory support
- Polyphenol intake
How it works
- Proanthocyanidin antioxidant activity
- Polyphenol-mediated oxidative stress reduction
- Anti-inflammatory signaling
- Vascular endothelial nitric oxide support
Dosage
- Typical range
- 150-400 mg daily
- Timing
- With meals
- With food
- Recommended; fat-soluble polyphenols benefit from dietary fat context
- Duration
- Safe for long-term use
- Special populations
- Bleeding disorders or anticoagulant use: caution with high doses; pregnancy/nursing: use food-level amounts
Forms
- Seed and Skin Powder· 70/100
Safety
Common side effects
- Minimal
- Mild headache or nausea possible at high doses
Contraindications
- Grape allergies
Evidence notes
Grape seed/skin extracts have moderate evidence for cardiovascular and antioxidant benefits. Muscadine-specific human clinical data is more limited than for European grape extracts, warranting a more conservative grade.
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.