Antioxidant
Pomegranate Extract
Also known as: Pomegranate, Punica granatum, Pomegranate polyphenols, Ellagic acid
Potent antioxidant fruit extract rich in punicalagins and ellagic acid. Supports cardiovascular health, exercise performance, and prostate health.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Pomegranate Extract product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne Hormone Advantage | 90 A | $0.85 |
| 2 | Seed DS-01® Daily Synbiotic | 90 A | $1.67 |
| 3 | Thorne Ovarian Care | 86 A- | $0.42 |
| 4 | Pure Encapsulations SP Ultimate | 84 A- | $2.23 |
| 5 | Life Extension Pomegranate Fruit Extract | 84 A- | $0.50 |
| 6 | Pure Encapsulations Men's Pure Pack | 82 A- | $3.08 |
| 7 | NOW Foods Clinical Strength Prostate Health | 82 A- | $0.97 |
| 8 | Pure Encapsulations Women's Pure Pack | 80 A- | $3.20 |
| 9 | Thorne Daily Greens Plus | 79 B+ | $0.83 |
| 10 | Pure Encapsulations Vascular Relax | 79 B+ | $1.38 |
| 11 | Pure Encapsulations Pomegranate Plus | 79 B+ | $0.60 |
| 12 | Pure Encapsulations Poly-Prebiotic powder | 79 B+ | $1.47 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Pomegranate Extract should I take?
The typical range is 100-500 mg extract or 200-500 mL juice daily. Safe long-term
When should I take Pomegranate Extract?
Any time. Optional.
Which form of Pomegranate Extract is best?
Standardized extract — Punicalagins or ellagic acid standardized. Other forms in the catalog: Whole fruit extract, Juice concentrate.
Is Pomegranate Extract safe?
Commonly reported: Generally well tolerated, Rare GI upset. Serious warnings: None significant. Safe
Which Pomegranate Extract supplement scores highest?
Thorne Hormone Advantage, at 90/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Antioxidant support
- Cardiovascular health
- Exercise recovery
- Prostate health
What systematic reviews concluded
Outcomes that systematic reviews of Pomegranate Extract reached a verdict on: 6 with a benefit, 3 with no effect, 4 unclear. Each is quoted from a review and linked to it on PubMed. How these were read.
Reviews found a benefit (6)
“pomegranate intake significantly increased HDL-C levels (mean difference: 2.50 mg/dL, 95 % CI: 1.00-4.00, p < 0.05)” PMID 40216355 · 2 reviews
“The current meta-analysis revealed that PJ supplemantation has a beneficial effect in improving CRP levels.” PMID 38553998
“Pomegranate can significantly improve hot flashes severity and menopause symptoms and decrease FSH.” PMID 37929766
“Meta-analysis of 14 clinical trials (n = 573 individuals) demonstrated a reduction in systolic BP (SBP) with pomegranate juice (MD: -5.02 mmHg, 95% CI: -7.55 to -2.48, p < 0.001).” PMID 37461211
“A wide range of plant preparations have been found to have a positive action, with pomegranate and some of its components being the best characterized” PMID 28212288
“We found a significant effect of pomegranate supplementation on hs-CRP, IL-6 and TNF-α in adults.” PMID 32147056
Reviews found no effect (3)
“no significant changes were observed in TC, LDL-C, or TG.” PMID 40216355
“It significantly improves high-density lipoprotein but not low-density lipoprotein, body mass index, and weight.” PMID 37929766
“However, the effects of pomegranate supplementation on CRP, E-selectin, ICAM, VCAM or MDA were not significant in this meta-analysis.” PMID 32147056
Not enough to say: inflammation in rheumatic diseases; cardiometabolic risk factors; insulin resistance; nonalcoholic fatty liver disease.
How it works
- Rich in punicalagins and ellagic acid
- Powerful antioxidant activity
- Supports nitric oxide production
- May inhibit aromatase
- Anti-inflammatory effects
Dosage
- Typical range
- 100-500 mg extract or 200-500 mL juice daily
- Timing
- Any time
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- Cardiovascular support, athletes, prostate health
Forms
- Standardized extract
- Whole fruit extract
- Juice concentrate
Safety
Common side effects
- Generally well tolerated
- Rare GI upset
Contraindications
- None known
Products containing Pomegranate Extract
Top-scoring supplements in our catalog that list Pomegranate Extract on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Good evidence for antioxidant effects and cardiovascular benefits
Grade B: Some human trials support key claims; further confirmation needed.
Related in Antioxidant
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Pomegranate Extract fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.