Antioxidant
POMELLA® Pomegranate Extract (Punica granatum fruit)
Also known as: pomegranate extract, pomegranate fruit extract, Punica granatum, pomegranate polyphenol extract
POMELLA is a standardized pomegranate fruit extract rich in ellagic acid and punicalagins, polyphenols with antioxidant and anti-inflammatory properties. Research suggests benefits for cardiovascular health, blood pressure, and cognitive function, though evidence remains moderate.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every POMELLA® Pomegranate Extract (Punica granatum fruit) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne Hormone Advantage | 90 A | $0.85 |
| 2 | Thorne Ovarian Care | 86 A- | $0.42 |
| 3 | Pure Encapsulations SP Ultimate | 84 A- | $2.23 |
| 4 | Life Extension Pomegranate Fruit Extract | 84 A- | $0.50 |
| 5 | Pure Encapsulations Men's Pure Pack | 82 A- | $3.08 |
| 6 | NOW Foods Clinical Strength Prostate Health | 82 A- | $0.97 |
| 7 | Pure Encapsulations Women's Pure Pack | 80 A- | $3.20 |
| 8 | Thorne Daily Greens Plus | 79 B+ | $0.83 |
| 9 | Pure Encapsulations Vascular Relax | 79 B+ | $1.38 |
| 10 | Pure Encapsulations Pomegranate Plus | 79 B+ | $0.60 |
| 11 | Pure Encapsulations Poly-Prebiotic powder | 79 B+ | $1.47 |
| 12 | Pure Encapsulations Acai 600 | 79 B+ | $0.37 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much POMELLA® Pomegranate Extract (Punica granatum fruit) should I take?
The typical range is 250-500 mg daily (standardized extracts). Consistent daily use for 8-12 weeks typically needed to observe cardiovascular benefits
When should I take POMELLA® Pomegranate Extract (Punica granatum fruit)?
With meals for optimal absorption. Recommended; fat-soluble polyphenols absorb better with food.
Which form of POMELLA® Pomegranate Extract (Punica granatum fruit) is best?
Capsule. Other forms in the catalog: Powder, Liquid extract.
Is POMELLA® Pomegranate Extract (Punica granatum fruit) safe?
Commonly reported: Generally well-tolerated, Rare: mild gastrointestinal upset at high doses, Rare: constipation.
Which POMELLA® Pomegranate Extract (Punica granatum fruit) supplement scores highest?
Thorne Hormone Advantage, at 90/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Antioxidant support
- Cardiovascular health
- Blood pressure regulation
- Cognitive function
- Anti-inflammatory support
How it works
- Polyphenol-mediated antioxidant activity (ellagic acid, punicalagins)
- Reduction of oxidative stress and free radicals
- Anti-inflammatory cytokine modulation
- Endothelial function improvement
Dosage
- Typical range
- 250-500 mg daily (standardized extracts)
- Timing
- With meals for optimal absorption
- With food
- Recommended; fat-soluble polyphenols absorb better with food
- Duration
- Consistent daily use for 8-12 weeks typically needed to observe cardiovascular benefits
- Special populations
- Generally safe; those on anticoagulants should consult healthcare provider due to potential additive effects
Forms
- Capsule· 70/100
- Powder· 70/100
- Liquid extract· 70/100
Safety
Common side effects
- Generally well-tolerated
- Rare: mild gastrointestinal upset at high doses
- Rare: constipation
Contraindications
- Concurrent use with anticoagulant medications (warfarin, etc.) — potential additive effects
- Concurrent use with antiplatelet agents — use cautiously and monitor
Products containing POMELLA® Pomegranate Extract (Punica granatum fruit)
Top-scoring supplements in our catalog that list POMELLA® Pomegranate Extract (Punica granatum fruit) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Pomegranate extract has multiple published RCTs supporting cardiovascular and antioxidant benefits, with consistent effects on blood pressure and endothelial function. POMELLA specifically is well-standardized and studied, but long-term efficacy data is limited compared to established cardiovascular agents.
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.