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Antioxidant

POMELLA® Pomegranate Extract (Punica granatum fruit)

Also known as: pomegranate extract, pomegranate fruit extract, Punica granatum, pomegranate polyphenol extract

B
Evidence

POMELLA is a standardized pomegranate fruit extract rich in ellagic acid and punicalagins, polyphenols with antioxidant and anti-inflammatory properties. Research suggests benefits for cardiovascular health, blood pressure, and cognitive function, though evidence remains moderate.

Primary uses

  • Antioxidant support
  • Cardiovascular health
  • Blood pressure regulation
  • Cognitive function
  • Anti-inflammatory support

How it works

  • Polyphenol-mediated antioxidant activity (ellagic acid, punicalagins)
  • Reduction of oxidative stress and free radicals
  • Anti-inflammatory cytokine modulation
  • Endothelial function improvement

Dosage

Typical range
250-500 mg daily (standardized extracts)
Timing
With meals for optimal absorption
With food
Recommended; fat-soluble polyphenols absorb better with food
Duration
Consistent daily use for 8-12 weeks typically needed to observe cardiovascular benefits
Special populations
Generally safe; those on anticoagulants should consult healthcare provider due to potential additive effects

Forms

  • Capsule· 70/100
  • Powder· 70/100
  • Liquid extract· 70/100

Safety

Common side effects

  • Generally well-tolerated
  • Rare: mild gastrointestinal upset at high doses
  • Rare: constipation

Contraindications

  • Concurrent use with anticoagulant medications (warfarin, etc.) — potential additive effects
  • Concurrent use with antiplatelet agents — use cautiously and monitor

Evidence notes

Pomegranate extract has multiple published RCTs supporting cardiovascular and antioxidant benefits, with consistent effects on blood pressure and endothelial function. POMELLA specifically is well-standardized and studied, but long-term efficacy data is limited compared to established cardiovascular agents.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.