Antioxidant
Polygonum cuspidatum Extract (98% Trans-Resveratrol)
Also known as: Japanese Knotweed Extract, Resveratrol, Trans-Resveratrol, Polygonum extract
A polyphenol extract from Japanese knotweed root standardized to 98% trans-resveratrol, a compound studied for antioxidant and cardiovascular support properties. Evidence supports resveratrol's antioxidant activity in vitro and some human studies, though clinical outcomes remain modest.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Antioxidant support
- Cardiovascular health
- Anti-aging/longevity
- Sirtuin activation
How it works
- NAD+-dependent deacetylase (sirtuin) activation
- Free radical scavenging and antioxidant activity
- Mitochondrial function support
- Anti-inflammatory signaling
Dosage
- Typical range
- 150-500 mg daily
- Timing
- With meals to improve absorption
- With food
- Recommended; fat-soluble polyphenol benefits from dietary fat
- Duration
- Chronic use (8+ weeks) generally studied; benefits may require sustained intake
- Special populations
- Pregnant/nursing women should consult healthcare provider; may interact with hormone therapies
Forms
- Capsule· 70/100
- Powder· 70/100
- Tablet· 70/100
Safety
Common side effects
- Generally well-tolerated at standard doses
- Mild gastrointestinal upset (rare)
- Headache (rare)
Contraindications
- Pregnancy and lactation (limited safety data)
- Estrogen-sensitive conditions (may have weak estrogenic activity)
- History of cancer (conflicting data; consult provider)
Products containing Polygonum cuspidatum Extract (98% Trans-Resveratrol)
Top-scoring supplements in our catalog that list Polygonum cuspidatum Extract (98% Trans-Resveratrol) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Resveratrol has solid mechanistic evidence in vitro and animal models; human RCTs show modest benefits for cardiovascular markers and antioxidant status, but clinical outcomes are inconsistent. The 98% standardization is a strength for quality control.
Grade B: Some human trials support key claims; further confirmation needed.
Cited research for Polygonum cuspidatum Extract (98% Trans-Resveratrol)
Clinical studies referenced across Formulate guides that mention polygonum cuspidatum extract (98% trans-resveratrol). Each links to the full study page with PubMed source + the guides that cite it.
- Koushki M, Dashatan NA, Meshkani R (2018)Clinical Therapeutics
Resveratrol supplementation gut microbiota and brain function: a systematic review
- Timmers S, Konings E, Bilet L, et al. (2011)Cell Metabolism
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.