Antioxidant
Polygonum cuspidatum Extract (98% Trans-Resveratrol)
Also known as: Japanese Knotweed Extract, Resveratrol, Trans-Resveratrol, Polygonum extract
A polyphenol extract from Japanese knotweed root standardized to 98% trans-resveratrol, a compound studied for antioxidant and cardiovascular support properties. Evidence supports resveratrol's antioxidant activity in vitro and some human studies, though clinical outcomes remain modest.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Polygonum cuspidatum Extract (98% Trans-Resveratrol) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Pure Encapsulations Resveratrol | 90 A | $0.47 |
| 2 | Pure Encapsulations Renual | 90 A | $2.63 |
| 3 | Thorne Advanced Nutrients | 88 A | $2.40 |
| 4 | Thorne SynaQuell +™ | 88 A | $1.47 |
| 5 | Nutricost Resveratrol Capsules | 88 A | $0.21 |
| 6 | Thorne L-Arginine Plus | 87 A | $1.25 |
| 7 | Thorne PolyResveratrol-SR® | 87 A | $1.97 |
| 8 | Pure Encapsulations NR Longevity | 87 A | $2.17 |
| 9 | Pure Encapsulations Mitochondria-ATP | 86 A- | $1.37 |
| 10 | Pure Encapsulations Memory Pro | 85 A- | $2.23 |
| 11 | Pure Encapsulations Metabolic Xtra | 85 A- | $0.63 |
| 12 | Thorne ResveraCel | 84 A- | $2.00 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Polygonum cuspidatum Extract (98% Trans-Resveratrol) should I take?
The typical range is 150-500 mg daily. Chronic use (8+ weeks) generally studied; benefits may require sustained intake
When should I take Polygonum cuspidatum Extract (98% Trans-Resveratrol)?
With meals to improve absorption. Recommended; fat-soluble polyphenol benefits from dietary fat.
Which form of Polygonum cuspidatum Extract (98% Trans-Resveratrol) is best?
Capsule. Other forms in the catalog: Powder, Tablet.
Is Polygonum cuspidatum Extract (98% Trans-Resveratrol) safe?
Commonly reported: Generally well-tolerated at standard doses, Mild gastrointestinal upset (rare), Headache (rare).
Which Polygonum cuspidatum Extract (98% Trans-Resveratrol) supplement scores highest?
Pure Encapsulations Resveratrol, at 90/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Antioxidant support
- Cardiovascular health
- Anti-aging/longevity
- Sirtuin activation
How it works
- NAD+-dependent deacetylase (sirtuin) activation
- Free radical scavenging and antioxidant activity
- Mitochondrial function support
- Anti-inflammatory signaling
Dosage
- Typical range
- 150-500 mg daily
- Timing
- With meals to improve absorption
- With food
- Recommended; fat-soluble polyphenol benefits from dietary fat
- Duration
- Chronic use (8+ weeks) generally studied; benefits may require sustained intake
- Special populations
- Pregnant/nursing women should consult healthcare provider; may interact with hormone therapies
Forms
- Capsule· 70/100
- Powder· 70/100
- Tablet· 70/100
Safety
Common side effects
- Generally well-tolerated at standard doses
- Mild gastrointestinal upset (rare)
- Headache (rare)
Contraindications
- Pregnancy and lactation (limited safety data)
- Estrogen-sensitive conditions (may have weak estrogenic activity)
- History of cancer (conflicting data; consult provider)
Products containing Polygonum cuspidatum Extract (98% Trans-Resveratrol)
Top-scoring supplements in our catalog that list Polygonum cuspidatum Extract (98% Trans-Resveratrol) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Resveratrol has solid mechanistic evidence in vitro and animal models; human RCTs show modest benefits for cardiovascular markers and antioxidant status, but clinical outcomes are inconsistent. The 98% standardization is a strength for quality control.
Grade B: Some human trials support key claims; further confirmation needed.
Cited research for Polygonum cuspidatum Extract (98% Trans-Resveratrol)
Clinical studies referenced across Formulate guides that mention polygonum cuspidatum extract (98% trans-resveratrol). Each links to the full study page with PubMed source + the guides that cite it.
- Koushki M, Dashatan NA, Meshkani R (2018)Clinical Therapeutics
Resveratrol supplementation gut microbiota and brain function: a systematic review
- Timmers S, Konings E, Bilet L, et al. (2011)Cell Metabolism
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.