Antioxidant

Trans-Resveratrol (from Polygonum cuspidatum root extract)

Also known as: resveratrol, trans-resveratrol, polygonum extract, Japanese knotweed

Evidence

A polyphenolic compound extracted from Polygonum cuspidatum (Japanese knotweed) root with potent antioxidant and sirtuin-activating properties. Trans-resveratrol is the bioactive isomer found in high concentrations in knotweed root.

Primary uses

Antioxidant support
Sirtuin activation (NAD+-dependent pathways)
Cardiovascular health
Cellular longevity

How it works

Direct sirtuin (SIRT1, SIRT3) activation
AMPK pathway stimulation
mTOR pathway modulation
Free radical scavenging
NAD+ metabolism support

Dosage

Typical range: 150–500 mg daily (trans-resveratrol content)
Timing: With meals for improved absorption and bioavailability
With food: With food; bioavailability significantly enhanced with fat
Duration: Safe for long-term use; effects may improve with consistent dosing over weeks to months
Special populations: Those on blood thinners or with hormone-sensitive cancers should consult healthcare provider before high-dose supplementation

Forms

capsule· 70/100
powder· 70/100
softgel· 70/100

Safety

Common side effects

Generally well-tolerated; rare mild GI upset or headache

Contraindications

Caution with anticoagulants at very high doses; theoretical concern with hormone-sensitive cancers (human evidence limited)

Evidence notes

Good evidence in animal and cell models for sirtuin activation and cardiovascular support; moderate human evidence. Polygonum cuspidatum is a rich, well-characterized source of trans-resveratrol.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.