Antioxidant
Trans-Resveratrol (from Polygonum cuspidatum root extract)
Also known as: resveratrol, trans-resveratrol, polygonum extract, Japanese knotweed
A polyphenolic compound extracted from Polygonum cuspidatum (Japanese knotweed) root with potent antioxidant and sirtuin-activating properties. Trans-resveratrol is the bioactive isomer found in high concentrations in knotweed root.
Primary uses
- Antioxidant support
- Sirtuin activation (NAD+-dependent pathways)
- Cardiovascular health
- Cellular longevity
How it works
- Direct sirtuin (SIRT1, SIRT3) activation
- AMPK pathway stimulation
- mTOR pathway modulation
- Free radical scavenging
- NAD+ metabolism support
Dosage
- Typical range
- 150–500 mg daily (trans-resveratrol content)
- Timing
- With meals for improved absorption and bioavailability
- With food
- With food; bioavailability significantly enhanced with fat
- Duration
- Safe for long-term use; effects may improve with consistent dosing over weeks to months
- Special populations
- Those on blood thinners or with hormone-sensitive cancers should consult healthcare provider before high-dose supplementation
Forms
- capsule· 70/100
- powder· 70/100
- softgel· 70/100
Safety
Common side effects
- Generally well-tolerated; rare mild GI upset or headache
Contraindications
- Caution with anticoagulants at very high doses; theoretical concern with hormone-sensitive cancers (human evidence limited)
Products containing Trans-Resveratrol (from Polygonum cuspidatum root extract)
Top-scoring supplements in our catalog that list Trans-Resveratrol (from Polygonum cuspidatum root extract) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
See all products →
Evidence notes
Good evidence in animal and cell models for sirtuin activation and cardiovascular support; moderate human evidence. Polygonum cuspidatum is a rich, well-characterized source of trans-resveratrol.
Grade B: Some human trials support key claims; further confirmation needed.
Cited research for Trans-Resveratrol (from Polygonum cuspidatum root extract)
Clinical studies referenced across Formulate guides that mention trans-resveratrol (from polygonum cuspidatum root extract). Each links to the full study page with PubMed source + the guides that cite it.
- Koushki M, Dashatan NA, Meshkani R (2018)Clinical Therapeutics
Resveratrol supplementation gut microbiota and brain function: a systematic review
- Timmers S, Konings E, Bilet L, et al. (2011)Cell Metabolism
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
Related in Antioxidant
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerMedical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.