Antioxidant

Trans-Resveratrol (from Polygonum cuspidatum root extract)

Also known as: resveratrol, trans-resveratrol, polygonum extract, Japanese knotweed

Evidence

A polyphenolic compound extracted from Polygonum cuspidatum (Japanese knotweed) root with potent antioxidant and sirtuin-activating properties. Trans-resveratrol is the bioactive isomer found in high concentrations in knotweed root.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

Add Pure Encapsulations Resveratrol to your stack — free

The highest-scored Trans-Resveratrol (from Polygonum cuspidatum root extract) product in our catalog (90/100). Track dose and overlaps in the app.

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Every Trans-Resveratrol (from Polygonum cuspidatum root extract) product we have scored

#	Product	Score	Per serving
1	Pure Encapsulations Resveratrol	90 A	$0.47
2	Pure Encapsulations Renual	90 A	$2.63
3	Thorne Advanced Nutrients	88 A	$2.40
4	Thorne SynaQuell +™	88 A	$1.47
5	Nutricost Resveratrol Capsules	88 A	$0.21
6	Thorne L-Arginine Plus	87 A	$1.25
7	Thorne PolyResveratrol-SR®	87 A	$1.97
8	Pure Encapsulations NR Longevity	87 A	$2.17
9	Pure Encapsulations Mitochondria-ATP	86 A-	$1.37
10	Pure Encapsulations Memory Pro	85 A-	$2.23
11	Pure Encapsulations Metabolic Xtra	85 A-	$0.63
12	Thorne ResveraCel	84 A-	$2.00

Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.

Common questions

How much Trans-Resveratrol (from Polygonum cuspidatum root extract) should I take?

The typical range is 150–500 mg daily (trans-resveratrol content). Safe for long-term use; effects may improve with consistent dosing over weeks to months

When should I take Trans-Resveratrol (from Polygonum cuspidatum root extract)?

With meals for improved absorption and bioavailability. With food; bioavailability significantly enhanced with fat.

Which form of Trans-Resveratrol (from Polygonum cuspidatum root extract) is best?

capsule. Other forms in the catalog: powder, softgel.

Is Trans-Resveratrol (from Polygonum cuspidatum root extract) safe?

Commonly reported: Generally well-tolerated; rare mild GI upset or headache.

Which Trans-Resveratrol (from Polygonum cuspidatum root extract) supplement scores highest?

Pure Encapsulations Resveratrol, at 90/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.

Primary uses

Antioxidant support
Sirtuin activation (NAD+-dependent pathways)
Cardiovascular health
Cellular longevity

How it works

Direct sirtuin (SIRT1, SIRT3) activation
AMPK pathway stimulation
mTOR pathway modulation
Free radical scavenging
NAD+ metabolism support

Dosage

Typical range: 150–500 mg daily (trans-resveratrol content)
Timing: With meals for improved absorption and bioavailability
With food: With food; bioavailability significantly enhanced with fat
Duration: Safe for long-term use; effects may improve with consistent dosing over weeks to months
Special populations: Those on blood thinners or with hormone-sensitive cancers should consult healthcare provider before high-dose supplementation

Forms

capsule· 70/100
powder· 70/100
softgel· 70/100

Safety

Common side effects

Generally well-tolerated; rare mild GI upset or headache

Contraindications

Caution with anticoagulants at very high doses; theoretical concern with hormone-sensitive cancers (human evidence limited)

Products containing Trans-Resveratrol (from Polygonum cuspidatum root extract)

Top-scoring supplements in our catalog that list Trans-Resveratrol (from Polygonum cuspidatum root extract) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Pure Encapsulations

Pure Encapsulations

Thorne

Thorne

Evidence notes

Good evidence in animal and cell models for sirtuin activation and cardiovascular support; moderate human evidence. Polygonum cuspidatum is a rich, well-characterized source of trans-resveratrol.

Grade B: Some human trials support key claims; further confirmation needed.

Cited research for Trans-Resveratrol (from Polygonum cuspidatum root extract)

Clinical studies referenced across Formulate guides that mention trans-resveratrol (from polygonum cuspidatum root extract). Each links to the full study page with PubMed source + the guides that cite it.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.