Antioxidant
Resveratrol
Also known as: Trans-resveratrol
Polyphenol from grapes activating longevity pathways. Sirtuin activator studied for cardiovascular and anti-aging benefits.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Resveratrol product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Pure Encapsulations Resveratrol | 90 A | $0.47 |
| 2 | Pure Encapsulations Renual | 90 A | $2.63 |
| 3 | Thorne Advanced Nutrients | 88 A | $2.40 |
| 4 | Thorne SynaQuell +™ | 88 A | $1.47 |
| 5 | Nutricost Resveratrol Capsules | 88 A | $0.21 |
| 6 | Thorne L-Arginine Plus | 87 A | $1.25 |
| 7 | Thorne PolyResveratrol-SR® | 87 A | $1.97 |
| 8 | Pure Encapsulations NR Longevity | 87 A | $2.17 |
| 9 | Pure Encapsulations Mitochondria-ATP | 86 A- | $1.37 |
| 10 | Pure Encapsulations Memory Pro | 85 A- | $2.23 |
| 11 | Pure Encapsulations Metabolic Xtra | 85 A- | $0.63 |
| 12 | Thorne ResveraCel | 84 A- | $2.00 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Resveratrol should I take?
The typical range is 150-500 mg daily. Safe long-term
When should I take Resveratrol?
With food. Yes, with fat.
Which form of Resveratrol is best?
Trans-resveratrol capsules — Active form. Other forms in the catalog: With pterostilbene.
Is Resveratrol safe?
Commonly reported: GI upset at high doses. Serious warnings: Estrogenic effects possible. Safe
Which Resveratrol supplement scores highest?
Pure Encapsulations Resveratrol, at 90/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Longevity
- Cardiovascular health
- Anti-aging
- Inflammation
What systematic reviews concluded
Outcomes that systematic reviews of Resveratrol reached a verdict on: 5 with a benefit, 3 with no effect, 5 unclear. Each is quoted from a review and linked to it on PubMed. How these were read.
Reviews found a benefit (5)
“synbiotics, soy isoflavones, naringin, curcumin, and resveratrol effectively improve bone mineral density, restore gut microbiota balance, and inhibit pathological bone resorption via the gut-bone axis.” PMID 42352378 · 2 reviews
“reduce total cholesterol among overweight adults.” PMID 41987155
“lower blood pressure among patients with type 2 diabetes” PMID 41987155
“it led to a significant reduction in waist circumference.” PMID 41455817 · 2 reviews
“Meta-analytic findings demonstrated that adjunctive natural products significantly enhanced probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain compared with SRP alone, with additional improvements in gingival inflammation and bleeding outcomes” PMID 41828611
Reviews found no effect (3)
“resveratrol supplementation was not considered as a beneficial agent in declining glycemic indices and lipid profile in patients with T2DM.” PMID 42268476
“This meta-analysis showed that resveratrol supplementation did not significantly impact most anthropometric measures and serum leptin and adiponectin in individuals with overweight and obesity.” PMID 41455817
“Resveratrol had no effect.” PMID 41483781
Not enough to say: sleep quality; non-alcoholic fatty liver disease markers; insulin sensitivity and lipid metabolism; glucose metabolism, renal function, endothelial health, working memory, hepatic steatosis, hormones and inflammation; obesity-related metabolic and inflammatory parameters.
2 findings from reviews in specific patient groups (such as cancer, pregnancy or surgery) are not shown here.
How it works
- Activates SIRT1 and AMPK
- Anti-inflammatory
- Cardiovascular protection
Dosage
- Typical range
- 150-500 mg daily
- Timing
- With food
- With food
- Yes, with fat
- Duration
- Safe long-term
- Special populations
- Longevity, cardiovascular focus
Forms
- Trans-resveratrol capsules
- With pterostilbene
Safety
Common side effects
- GI upset at high doses
Contraindications
- Hormone-sensitive cancers (caution)
Products containing Resveratrol
Top-scoring supplements in our catalog that list Resveratrol on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Known interactions
Evidence notes
Sirtuin activator; mixed human evidence
Grade B: Some human trials support key claims; further confirmation needed.
Cited research for Resveratrol
Clinical studies referenced across Formulate guides that mention resveratrol. Each links to the full study page with PubMed source + the guides that cite it.
- Koushki M, Dashatan NA, Meshkani R (2018)Clinical Therapeutics
Resveratrol supplementation gut microbiota and brain function: a systematic review
- Timmers S, Konings E, Bilet L, et al. (2011)Cell Metabolism
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
Resveratrol compared head-to-head
Related in Antioxidant
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.