Polyphenols & Longevity
Pterostilbene vs Resveratrol
Pterostilbene has 4× the bioavailability and a longer half-life — it's the better-absorbed cousin.
Both are stilbene polyphenols with overlapping benefits: sirtuin activation, antioxidant activity, anti-inflammatory effects. Resveratrol has more research volume but suffers from rapid glucuronidation — most of an oral dose is cleared before it acts. Pterostilbene has two methyl groups that slow clearance, yielding ~80% oral bioavailability vs resveratrol's ~20%.
Antioxidant
Methylated resveratrol with 4x better bioavailability. Similar longevity pathway activation.
Typical dose: 50-150 mg daily
Main uses: Longevity · Cognitive function · Cardiovascular health
Full Pterostilbene profile →Antioxidant
Polyphenol from grapes activating longevity pathways. Sirtuin activator studied for cardiovascular and anti-aging benefits.
Typical dose: 150-500 mg daily
Main uses: Longevity · Cardiovascular health · Anti-aging
Full Resveratrol profile →When to pick Pterostilbene
Pick Pterostilbene for practical NAD+ / sirtuin support at a lower dose. 50–150 mg/day matches what 250–500 mg resveratrol tries to do on paper. Less well-studied but pharmacokinetically superior.
When to pick Resveratrol
Pick Resveratrol if you want the larger clinical trial record and don't mind taking more of it. Effective dose is 150–500 mg with a fat source. Micronized or liposomal formulations narrow the bioavailability gap.
Can you take them together?
Often stacked in longevity formulas (alongside NMN). The two polyphenols overlap mechanistically but aren't redundant — they hit SIRT1 and SIRT3 with slightly different kinetics. No drug interactions at supplement doses.
FAQ
Pterostilbene vs Resveratrol: which is better?
Pterostilbene has 4× the bioavailability and a longer half-life — it's the better-absorbed cousin.
Is Pterostilbene safer than Resveratrol?
Both have well-characterized safety profiles at the doses above. See each ingredient's dedicated page for specific contraindications. Always check the interaction checker before combining either with prescription medication.
Can I combine Pterostilbene and Resveratrol?
Often stacked in longevity formulas (alongside NMN). The two polyphenols overlap mechanistically but aren't redundant — they hit SIRT1 and SIRT3 with slightly different kinetics. No drug interactions at supplement doses.
Dig deeper
Educational only. This comparison is not medical advice. Discuss any new supplement with your clinician, especially if you take prescription medication or have a chronic condition.