What the reviews found
Supplements for Inflammation
27 where systematic reviews concluded a benefit, 5 with mixed findings, 6 where they concluded no effect. Every line quotes the review and links it, so you can read the sentence yourself.
Reviews found a benefit
Systematic reviews concluded these improve an outcome tied to inflammation, and none concluded no effect.
- 3 reviews citedTop-scored productLife Extension Pomegranate Fruit Extract84Benefitc-reactive protein
“The current meta-analysis revealed that PJ supplemantation has a beneficial effect in improving CRP levels.” PMID 38553998
Benefitinflammatory markers (il-6, tnf-α)“We found a significant effect of pomegranate supplementation on hs-CRP, IL-6 and TNF-α in adults.” PMID 32147056
- 2 reviews citedBenefitinflammatory markers (il-6, hs-crp) in obesity
“Improvements were also observed in abdominal fat and inflammatory markers such as interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP).” PMID 39062848
Benefitinflammatory markers in diabetes“These findings support the adjunctive use of targeted, SCFA-oriented probiotic formulations (e.g., Lactobacillus plantarum, Lactobacillus casei, Bifidobacterium longum with inulin/FOS, ≥10^9-10^10 CFU/day) to mitigate metabolic inflammation alongside standard care.” PMID 41059033
- 2 reviews citedTop-scored productThorne Super EPA92Benefitcrp inflammation(as Fish Oil)
“A daily dose <2000 mg of omega-3 fatty acids in natural triglyceride form appears more effective than synthetic ethyl ester formulations for lowering CRP in HD patients.” PMID 41692069
Benefitinterleukin-6 levels(as Omega-3 Fatty Acids)“combined omega-3 and arginine supplementation was more effective in decreasing interleukin-6 (MD -61.41; 95% CrI [-97.85, -24.85])” PMID 37375676
- 3 reviews citedTop-scored productPure Encapsulations Astaxanthin93Benefitc-reactive protein
“astaxanthin, (WMD: ‒0.30 mg/L, 95% CI: ‒0.51, ‒0.09, P = 0.005), lutein/zeaxanthin (WMD: ‒0.30 mg/L, 95% CI: ‒0.45, ‒0.15, P < 0.001), and β-cryptoxanthin (WMD: ‒0.35 mg/L, 95% CI: ‒0.54, ‒0.15, P < 0.001) significantly decreased CRP level.” PMID 33998846
- 3 reviews citedTop-scored productThorne Berberine96Benefitinflammatory markers
“These interventions significantly mitigate IL-6 levels (-1.18 pg/mL), TNF-α levels (-3.72 pg/mL), and CRP levels (-1.33 mg/L).” PMID 37675930 · 3 reviews
- Cinnamon2 reviews citedBenefitoxidative stress and inflammation biomarkers
“support the usefulness of cinnamon consumption in modulating BP as well as improving TAC and IL-6 in metabolic disorders.” PMID 39299867 · 2 reviews
- 2 reviews citedTop-scored productThorne Grape Seed Extract92Benefitc-reactive protein
“grape seed extract and other grape products, such as grape extract, juice and raisins, decreased CRP levels significantly.” PMID 32921322
- 2 reviews citedTop-scored productThorne Selenium96Benefiths-crp (inflammation)
“dietary selenium significantly reduced HOMA-β (Homeostasis Model Assessment-Beta; p < 0.0001), triglycerides (p = 0.02), high-sensitivity C-reactive protein (p < 0.00001), and plasma malondialdehyde (p < 0.00001), while increasing total antioxidant capacity (p = 0.04)” PMID 41738711
- 2 reviews citedBenefitc-reactive protein
“Our results confirmed a significant decreasing effect of TC on CRP.” PMID 35653966 · 2 reviews
- 1 review citedTop-scored productNootropics Depot Shoden® Ashwagandha Capsules95Benefitoxidative stress and inflammation(as Ashwagandha Brood-Spectrum)
“Participants supplemented with Ws displayed reduced levels of oxidative stress and inflammation, and counterbalanced hormone levels.” PMID 37428341
- 1 review citedBenefitinflammatory markers
“Probiotic/synbiotic interventions led to significant reductions in CRP (SMD = -0.54), IL-6 (SMD = -0.41), and TNF-α (SMD = -0.48), along with an increase in IL-10 (SMD = +0.38).” PMID 41059033
- 1 review citedTop-scored productThorne Boswellia Phytosome92Benefitinflammatory/pain conditions(as Boswellia Serrata)
“Boswellia serrata Roxb. was found to be the most promising, since it shows the best efficacy for the treatment of pain/inflammatory conditions.” PMID 23391017
- 1 review citedTop-scored productNOW Foods Certified Organic Chlorella87Benefitc-reactive protein
“high-sensitivity C-reactive protein (hs-CRP) (WMD= -1.02, 95% CI: -1.84, -0.19)” PMID 41652544
- Chlorogenic Acid1 review citedBenefitc-reactive protein
“This meta-analysis shows that the use of GCBE supplements resulted in a statistical decrease in CRP levels, mainly for non-healthy subjects.” PMID 32951749
- 1 review citedTop-scored productNootropics Depot CoQH-CF Softgels97Benefitinflammatory markers
“CoQ10 supplementation has beneficial effects on lipid metabolism, glycemic control, and inflammation among individuals with metabolic disorders.” PMID 42192187
- 1 review citedTop-scored productPure Encapsulations Curcumin90Benefitinflammatory markers
“turmeric/curcumin supplementation significantly reduces levels of inflammatory markers, including CRP (WMD: -0.58 mg/l, 95 % CI: -0.74, -0.41), TNF-α (WMD: -3.48 pg/ml, 95 % CI: -4.38, -2.58), and IL-6 (WMD: -1.31 pg/ml, 95 % CI: -1.58, -0.67)” PMID 36804260
- 1 review citedTop-scored productPure Encapsulations Ginkgo 50 160 mg87Benefitinflammatory markers
“This meta-analysis showed that the GBLE could reduce serum inflammatory markers.” PMID 35781715
- 1 review citedTop-scored productMegaFood Baby & Me 2 Prenatal Probiotic + Prebiotic88Benefitinflammatory markers
“Probiotic/synbiotic interventions led to significant reductions in CRP (SMD = -0.54), IL-6 (SMD = -0.41), and TNF-α (SMD = -0.48), along with an increase in IL-10 (SMD = +0.38).” PMID 41059033
- 1 review citedTop-scored productThorne Magnesium Glycinate96Benefitinterleukin-6
“interleukin-6 levels (WMD: -1.10 pg/mL; 95% CI: -1.93, -0.27) compared with controls.” PMID 42588058
- 1 review citedTop-scored productPure Encapsulations Melatonin 3 mg92Benefitc-reactive protein
“C-reactive protein (WMD: -0.59 mg/L, 95% CI: -0.94, -0.23)” PMID 41515249
- Olive Oil1 review citedBenefitinflammation
“Available evidence suggests that a MED diet supplemented with olive oil compared with the LFD significantly improves inflammation and serum endothelial function in adults.” PMID 39530776
- 1 review citedTop-scored productNOW Foods Beta-Sitosterol Plant Sterols79Benefiths-crp
“small important improvements in apoB, hs-CRP and apoC-II” PMID 42275989
- 1 review citedTop-scored productThorne Red Yeast Rice92Benefitc-reactive protein
“"RYR plus conventional therapy" exhibited significant lowering effects on serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and CRP but exhibited no significant effect on systolic BP, diastolic BP, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) compared with "placebo plus conventional therapy."” PMID 26167669
- 1 review citedTop-scored productDouble Wood Spermidine Supplement88Benefitneuroinflammation
“The results imply a positive outlook for the reviewed substances to qualify as a novel treatment option for AD.” PMID 33353228
- 1 review citedTop-scored productNootropics Depot Taurine Capsules93Benefitinflammatory markers
“Given the dose-response relationship identified between taurine and inflammatory markers TNF-⍺ and IL-6, a daily dose of 3,000 mg appears to offer an optimal balance between clinical efficacy and tolerability.” PMID 41803812
- 1 review citedTop-scored productMomentous Vegan Vitamin D3 5000 IU Supplement95Benefitsystemic inflammation in autoimmune disease(as Cholecalciferol)
“Vitamin D3 effectively corrects deficiency and exerts modest, systemic anti-inflammatory effects in autoimmune patients.” PMID 41952022
- 1 review citedTop-scored productThorne Zinc Bisglycinate 30 mg96Benefitinflammation
“Zinc supplementation was associated with improvements in insulin resistance, inflammatory status and oxidative stress markers in individuals with diabetes.” PMID 42594341
Mixed: a benefit on one measure, no effect on another
- 1 review citedTop-scored productThorne Chromium Picolinate92Benefitinflammatory markers (crp, tnf-α)
“Our study supports the beneficial effect of chromium supplementation on serum concentration of CRP and TNF-α, but our results showed that chromium supplementation non-significantly reduced the serum levels of IL-6.” PMID 39671146
No effectil-6 levels“chromium supplementation resulted in a non-significant decrease in serum levels of IL-6 (WMD = -0.63 pg/ml; 95% CI: -1.67, 0.4 pg/ml; P < 0.001).” PMID 39671146
- 1 review citedTop-scored productThorne L-Glutamine Powder92Benefitcrp
“This study identified that glutamine supplementation might have an important effect on CRP in acute conditions and no significant effect on IL-6 and TNF-α in acute conditions.” PMID 34213769
No effectil-6 and tnf-α“no significant effect on IL-6 and TNF-α in acute conditions” PMID 34213769
- 1 review citedTop-scored productPure Encapsulations NAC 600 mg94Benefitil-6(as NAC)
“A substantial decrease was observed in concentrations of IL-6 (p = 0.03; the standardized MD (SMD) was -1.71; 95% CI, -3.26, -0.16) and TBARS (p = 0.02; SMD was -1.03, 95% CI, -1.90, -0.15).” PMID 39632267
No effecttnf-alpha and creatine kinase(as NAC)“However, we saw no significant effect of NAC on TNF-α, CK or GSSG concentrations.” PMID 39632267
- Oleic Acid1 review citedBenefitc-reactive protein
“increasing OA supplementation significantly reduced C-reactive protein (CRP) (SMD: -0.11, 95% CI: -0.21, -0.01, P = 0.038)” PMID 33305589
No effectinflammatory markers (tnf, il-6, fibrinogen, pai-1, sicam-1, svcam-1)“dietary OA consumption did not significantly affect tumor necrosis factor (TNF) (SMD: -0.05, 95% CI: -0.19, 0.10, P = 0.534), interleukin 6 (IL-6) (SMD: 0.01, 95% CI: -0.10, 0.13, P = 0.849), fibrinogen (SMD: 0.08, 95% CI: -0.16, 0.31, P = 0.520), plasminogen activator inhibitor type 1 (PAI-1) activity (SMD: -0.11, 95% CI: -0.34, 0.12, P = 0.355), soluble intercellular adhesion molecule-1 (sICAM-1) (SMD: -0.06, 95% CI: -0.26, 0.13, P = 0.595) or soluble vascular cell adhesion molecule-1 (sVCAM-1) (SMD: -0.04, 95% CI: -0.27, 0.18, P = 0.701)” PMID 33305589
- 1 review citedTop-scored productNOW Foods Certified Organic Spirulina87Benefitc-reactive protein
“The findings of this study indicated that Spirulina supplementation significantly reduced serum CRP levels, whereas its effects on IL-6 and TNF-α were not statistically significant.” PMID 41873104
No effectil-6 and tnf-alpha“The findings of this study indicated that Spirulina supplementation significantly reduced serum CRP levels, whereas its effects on IL-6 and TNF-α were not statistically significant.” PMID 41873104
Reviews found no effect
Reviews studied these for an outcome tied to inflammation and concluded they made no difference.
- 1 review citedTop-scored productNutricost TMG Capsules92No effectinflammatory markers
“The present meta-analysis does not provide sufficient evidence to conclude that betaine supplementation improved the inflammation state.” PMID 37733077
- Bilberry2 reviews citedNo effectinflammatory markers(as Vaccinium myrtillus)
“Vaccinium berry supplementation is not effective in modulating markers of exercise-induced inflammation and oxidative distress in healthy individuals” PMID 38165220 · 2 reviews
No effecths-crp“hs-CRP (WMD: -8.22 mg/L, 95% CI: -20.24% to 3.81%, p = 0.18)” PMID 40751398
No effectil-6“IL-6 (WMD: -7.19 pg/mL, 95% CI: -19.01% to 4.63%, p = 0.23)” PMID 40751398
- Catechins1 review citedNo effectc-reactive protein
“This meta-analysis of data from 11 RCT arms did not indicate a significant effect of supplementation with green tea catechins on plasma CRP concentrations.” PMID 26233863
- 1 review citedTop-scored productBulkSupplements L-Citrulline Powder91No effectinflammatory biomarkers and oxidative stress
“In conclusion, our systematic review and meta-analysis found that L-Citrulline and L-Arginine did not influence inflammatory biomarkers and oxidative stress after exercise.” PMID 37111214
- Melissa officinalis1 review citedNo effecths-crp
“MO intake was not associated with statistically significant changes in triglycerides, low-density lipoprotein, diastolic blood pressure, high sensitivity c-reactive protein levels, fasting blood sugar, HbA1c, insulin or high-density lipoprotein levels.” PMID 32614129
- Omega 6 Fatty Acids1 review citedNo effectinflammatory markers
“Our findings suggest that supplementation with PUFAs has little or no effect on prevention or treatment of IBD and provides little support for modification of long-term inflammatory status.” PMID 33084958
Not enough to say
Reviews of Bacillus subtilis, Bromelain, Ginger, Hordeum vulgare, Lignans, Oleuropein, Resveratrol, Vitamin C, Watermelon could not conclude either way on inflammation.
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How this page is built
Each finding is the conclusion a set of systematic reviews reached on one outcome — whether an ingredient helped, made no difference, or could not be judged — with a sentence quoted from one review, checked to appear in its PubMed abstract. It records the direction, not the size, of an effect. Reviews run in populations such as people with cancer, pregnancy, surgery or children are left out, because applying them to a general reader would mislead. Evidence last refreshed September 2026. Abstracts courtesy of the U.S. National Library of Medicine (PubMed). The full report explains how the conclusions were read and checked.
Other goals
Educational only. A review finding a benefit on average does not mean a supplement will help you, or that it is safe alongside your medication. If you are treated for inflammation, talk to your clinician before adding anything.