Probiotic
Lactobacillus plantarum
Also known as: L. plantarum, L. plantarum 299v, LP299v
Versatile probiotic with gut barrier support and anti-inflammatory effects. Found in fermented vegetables.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Lactobacillus plantarum product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Garden of Life Multi-Source Collagen Turmeric - Apple Cinnamon | 71 B | $1.29 |
| 2 | Thorne Women's Daily Probiotic | 69 B | $1.30 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Lactobacillus plantarum should I take?
The typical range is 5-20 billion CFU daily. Safe long-term
When should I take Lactobacillus plantarum?
Any time. Either way.
Which form of Lactobacillus plantarum is best?
Capsules — Often in blends. Other forms in the catalog: Foods.
Is Lactobacillus plantarum safe?
Commonly reported: Minimal. Serious warnings: Standard probiotic cautions. Safe
Which Lactobacillus plantarum supplement scores highest?
Garden of Life Multi-Source Collagen Turmeric - Apple Cinnamon, at 71/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Gut barrier
- IBS support
- Inflammation
- Gut health
What systematic reviews concluded
Outcomes that systematic reviews of Lactobacillus plantarum reached a verdict on: 6 with a benefit, 2 unclear. Each is quoted from a review and linked to it on PubMed. How these were read.
Reviews found a benefit (6)
“The analysis of nine studies revealed significant weight reduction and BMI decreases with L. plantarum supplementation compared to a placebo.” PMID 39062848
“Improvements were also observed in abdominal fat and inflammatory markers such as interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP).” PMID 39062848
“L. plantarum supplementation reduced the levels of fasting plasma glucose (-0.41, 95%CI -0.63, -0.19 mg/dL; n = 5) and hemoglobin A1c (-0.2, 95%CI: -0.3, 0%; n = 4).” PMID 38777458
“The main result of this research was that the use of Lactiplantibacillus plantarum alone or in combination produced improvements in symptomatology related to neurodegenerative disease.” PMID 38474254
“Probiotic strains such as Lactobacillus plantarum subspecies JYLP-326 and Bifidobacterium breve CCFM1025 were particularly effective, while multi-strain probiotics generally showed more consistent effects than single-strain interventions.” PMID 40669008
“These findings support the adjunctive use of targeted, SCFA-oriented probiotic formulations (e.g., Lactobacillus plantarum, Lactobacillus casei, Bifidobacterium longum with inulin/FOS, ≥10^9-10^10 CFU/day) to mitigate metabolic inflammation alongside standard care.” PMID 41059033
Not enough to say: periodontal clinical parameters; lipid profile and insulin resistance.
How it works
- Strengthens tight junctions
- Anti-inflammatory cytokine production
- Survives stomach acid well
Dosage
- Typical range
- 5-20 billion CFU daily
- Timing
- Any time
- With food
- Either way
- Duration
- Safe long-term
- Special populations
- IBS, leaky gut concerns
Forms
- Capsules
- Foods
Safety
Common side effects
- Minimal
Contraindications
- Severe immunocompromise
Products containing Lactobacillus plantarum
Top-scoring supplements in our catalog that list Lactobacillus plantarum on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Strong gut barrier support
Grade B: Some human trials support key claims; further confirmation needed.
Cited research for Lactobacillus plantarum
Clinical studies referenced across Formulate guides that mention lactobacillus plantarum. Each links to the full study page with PubMed source + the guides that cite it.
- Ford et al. (2014)American Journal of Gastroenterology
Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis
- Ducrotté et al. (2012)World Journal of Gastroenterology
Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome
Related in Probiotic
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.