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Probiotic

Bifidobacterium infantis 35624

Also known as: B. infantis 35624, Bifantis, Align probiotic, Bifidobacterium longum subsp. infantis 35624

B
Evidence

Most-studied probiotic strain for IBS. Repeated RCTs show symptom improvement at 1 billion CFU/day.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • IBS symptom relief
  • Abdominal pain
  • Bloating
  • Bowel regularity

How it works

  • Modulates intestinal cytokine balance (raises IL-10, lowers IL-6/TNF-alpha)
  • Restores gut barrier function in inflammatory states
  • Influences enteric nervous system signaling

Dosage

Typical range
1 billion CFU once daily
Timing
Same time daily
With food
With or without food per product directions
Duration
Trials show benefit emerging over 4 weeks; safe for long-term use
Special populations
Generally safe in pregnancy and pediatrics; consult provider in immunocompromised states

Forms

  • Capsule (single-strain)
  • Multi-strain blend

Safety

Common side effects

  • Transient gas or bloating in the first 1-2 weeks

Contraindications

  • Central venous catheters in critically ill patients

Evidence notes

Multiple RCTs in IBS show reduced abdominal pain, bloating, and urgency. Effect is strain-specific — generic B. infantis products may not deliver the same benefit.

Grade B: Some human trials support key claims; further confirmation needed.

Cited research for Bifidobacterium infantis 35624

Clinical studies referenced across Formulate guides that mention bifidobacterium infantis 35624. Each links to the full study page with PubMed source + the guides that cite it.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.