Longevity
Spermidine
Also known as: Spermidine polyamine
Polyamine that induces autophagy, the cellular recycling process. Found in wheat germ and aged cheese, associated with longevity in population studies.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Autophagy
- Longevity
- Cellular renewal
- Cardiovascular health
How it works
- Induces autophagy
- Supports cellular renewal
- Cardioprotective in studies
- Neuroprotective potential
Dosage
- Typical range
- 1-6mg daily
- Timing
- Any time
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- Longevity-focused, autophagy support
Forms
- Capsule
- Wheat germ powder
Safety
Common side effects
- Well tolerated
Contraindications
- None established
Evidence notes
Population studies link to longevity, autophagy induction confirmed
Grade B: Some human trials support key claims; further confirmation needed.
Related in Longevity
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.