Longevity
Spermidine
Also known as: Wheat germ spermidine
Polyamine that induces autophagy - cellular cleanup. Emerging longevity compound.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Autophagy
- Longevity
- Cellular cleanup
- Heart health
How it works
- Induces autophagy
- Cellular renewal
- May support heart and brain
Dosage
- Typical range
- 1-6mg spermidine daily
- Timing
- Any time
- With food
- Optional
- Duration
- Ongoing for longevity
- Special populations
- Anti-aging, autophagy focus
Forms
- Wheat germ extract
- Pure spermidine
Safety
Common side effects
- Rare
Contraindications
- None known
Evidence notes
Emerging autophagy inducer
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Longevity
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.