Longevity
NMN (Nicotinamide Mononucleotide)
Also known as: Nicotinamide mononucleotide, β-NMN, β-Nicotinamide Mononucleotide
Direct NAD+ precursor popularized by longevity research. Supports cellular repair and energy.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every NMN (Nicotinamide Mononucleotide) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Doctor's Best NMN + CoQ10, 150 mg, 60 Veggie Caps | 89 A | $1.07 |
| 2 | Transparent Labs Longevity Healthy Aging Complex | 87 A | $2.67 |
| 3 | ProHealth Longevity NMN Pro 1000™ | 86 A- | $2.17 |
| 4 | Transparent Labs NMN Supplement for NAD+ & Cellular Energy | 86 A- | $1.33 |
| 5 | ProHealth Longevity NMN Pro™ Powder - Uthever NMN, 15 Grams | 86 A- | $0.74 |
| 6 | Pure Encapsulations Mitochondria-ATP | 86 A- | $1.37 |
| 7 | Nutricost NMN | 86 A- | $0.44 |
| 8 | ProHealth Longevity NMN Pro™ Powder | 85 A- | $0.74 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much NMN (Nicotinamide Mononucleotide) should I take?
The typical range is 250-1000 mg daily. Long-term use
When should I take NMN (Nicotinamide Mononucleotide)?
Morning. Optional.
Which form of NMN (Nicotinamide Mononucleotide) is best?
Capsules — Common. Other forms in the catalog: Sublingual.
Is NMN (Nicotinamide Mononucleotide) safe?
Commonly reported: Mild GI upset. Serious warnings: None established. Safe
Which NMN (Nicotinamide Mononucleotide) supplement scores highest?
Doctor's Best NMN + CoQ10, 150 mg, 60 Veggie Caps, at 89/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- NAD+ support
- Longevity
- Energy
- Anti-aging
What systematic reviews concluded
Outcomes that systematic reviews of NMN (Nicotinamide Mononucleotide) reached a verdict on: 3 with a benefit, 3 with no effect, 5 unclear. Each is quoted from a review and linked to it on PubMed. How these were read.
Reviews found a benefit (3)
“Compared with the placebo, NMN supplementation was associated with a statistically significant but modest reduction in resting DBP (WMD, -2.15 mmHg; 95% CI: -3.68 to -0.61).” PMID 41901064
“Random-effects meta-analyses found an overall significant effect of NMN supplementation in elevating blood NAD levels.” PMID 39116016
“NMN supplementation shows improvements for oocyte function across diverse preclinical models.” PMID 41160202
Reviews found no effect (3)
“NMN did not increase overall, serious, withdrawal-related, or system-specific adverse events, nor did it significantly elevate ALT or AST.” PMID 42514320
“No significant effects were observed on body weight, BMI, fasting glucose, HbA1c, lipid profiles, or systolic blood pressure.” PMID 42514320
“The random-effects meta-analyses indicated no significant benefit of NMN on fasting glucose, fasting insulin, glycated hemoglobin, homeostatic model assessment for insulin resistance and lipid profile.” PMID 39531138
Not enough to say: liver enzymes; insulin resistance (homa-ir); systolic blood pressure; muscle mass and function; healthspan-related functional, metabolic, and vascular outcomes.
1 finding from reviews in specific patient groups (such as cancer, pregnancy or surgery) is not shown here.
How it works
- Direct precursor to NAD+
- Supports DNA repair
- Sirtuin activation
Dosage
- Typical range
- 250-1000 mg daily
- Timing
- Morning
- With food
- Optional
- Duration
- Long-term use
- Special populations
- Longevity-focused
Forms
- Capsules
- Sublingual
Safety
Common side effects
- Mild GI upset
Contraindications
- None known
Products containing NMN (Nicotinamide Mononucleotide)
Top-scoring supplements in our catalog that list NMN (Nicotinamide Mononucleotide) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Popular NAD+ precursor
Grade B: Some human trials support key claims; further confirmation needed.
NMN (Nicotinamide Mononucleotide) compared head-to-head
Related in Longevity
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does NMN (Nicotinamide Mononucleotide) fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.