Longevity

NR (Nicotinamide Riboside)

Also known as: Nicotinamide riboside, Niagen, NR chloride

Evidence

NAD+ precursor with extensive human safety data. First NAD+ precursor with significant clinical trials. Patented as Niagen.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

Find the best NR (Nicotinamide Riboside) supplements — free

See NR (Nicotinamide Riboside) products scored on dose & form, then track your intake in the app.

Open app →

Primary uses

NAD+ support
Cellular energy
Longevity
Healthy aging

How it works

Converted to NMN then NAD+
Supports sirtuin activity
Mitochondrial function
Cellular repair pathways

Dosage

Typical range: 250-500mg daily
Timing: Morning
With food: Can be taken with or without
Duration: Established safety profile
Special populations: Longevity, energy, healthy aging

Forms

Capsule

Safety

Common side effects

Well tolerated
Nausea rare
Flushing rare

Contraindications

None established

Products containing NR (Nicotinamide Riboside)

Top-scoring supplements in our catalog that list NR (Nicotinamide Riboside) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Evidence notes

Good human trial data, established safety profile

Grade B: Some human trials support key claims; further confirmation needed.

Related in Longevity

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Where does NR (Nicotinamide Riboside) fit in your stack?

Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.

Build my stack

2 questions · free · no account needed to start

Also on iPhone — get the free app

📬 Get new guides in your inbox

Evidence-based supplement guides, no spam

We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.