Longevity
NR (Nicotinamide Riboside)
Also known as: Nicotinamide riboside, Niagen, NR chloride
NAD+ precursor with extensive human safety data. First NAD+ precursor with significant clinical trials. Patented as Niagen.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every NR (Nicotinamide Riboside) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Life Extension NAD+ Cell Regenerator | 91 A | $0.60 |
| 2 | Thorne Advanced Nutrients | 88 A | $2.40 |
| 3 | Thorne SynaQuell +™ | 88 A | $1.47 |
| 4 | Pure Encapsulations NR Longevity | 87 A | $2.17 |
| 5 | Thorne Brain Factors | 84 A- | $1.70 |
| 6 | Thorne ResveraCel | 84 A- | $2.00 |
| 7 | Life Extension NAD+ Cell Regenerator and Resveratrol Elite | 84 A- | $1.50 |
| 8 | Thorne NiaCel® 400 | 81 A- | $1.23 |
| 9 | Thorne Daily Greens Plus | 79 B+ | $0.83 |
| 10 | Codeage Liposomal Nicotinamide Riboside+ Large | 78 B+ | $1.00 |
| 11 | Thorne Collagen Plus | 74 B+ | $2.23 |
| 12 | Thorne Collagen Fit | 73 B+ | $1.87 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much NR (Nicotinamide Riboside) should I take?
The typical range is 250-500mg daily. Established safety profile
When should I take NR (Nicotinamide Riboside)?
Morning. Can be taken with or without.
Which form of NR (Nicotinamide Riboside) is best?
Capsule — Niagen branded common.
Is NR (Nicotinamide Riboside) safe?
Commonly reported: Well tolerated, Nausea rare, Flushing rare. Serious warnings: None significant in trials. Safe
Which NR (Nicotinamide Riboside) supplement scores highest?
Life Extension NAD+ Cell Regenerator, at 91/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- NAD+ support
- Cellular energy
- Longevity
- Healthy aging
What systematic reviews concluded
Outcomes that systematic reviews of NR (Nicotinamide Riboside) reached a verdict on: 1 with a benefit, 1 with no effect, 3 unclear. Each is quoted from a review and linked to it on PubMed. How these were read.
Reviews found a benefit (1)
“oral NR and NMN consistently demonstrated biochemical target engagement (circulating (plasma/whole blood) or cellular (e.g., PBMC) NAD-related metabolites) and were generally well tolerated over weeks to months” PMID 41655607
Reviews found no effect (1)
“Current evidence does not support NMN and NR supplementation for preserving muscle mass and function in adults with mean age of over 60 years.” PMID 40275690
Not enough to say: cerebellar ataxia symptoms; healthspan-related functional and metabolic outcomes; mitochondrial function in healthy aging.
1 finding from reviews in specific patient groups (such as cancer, pregnancy or surgery) is not shown here.
How it works
- Converted to NMN then NAD+
- Supports sirtuin activity
- Mitochondrial function
- Cellular repair pathways
Dosage
- Typical range
- 250-500mg daily
- Timing
- Morning
- With food
- Can be taken with or without
- Duration
- Established safety profile
- Special populations
- Longevity, energy, healthy aging
Forms
- Capsule
Safety
Common side effects
- Well tolerated
- Nausea rare
- Flushing rare
Contraindications
- None established
Products containing NR (Nicotinamide Riboside)
Top-scoring supplements in our catalog that list NR (Nicotinamide Riboside) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Good human trial data, established safety profile
Grade B: Some human trials support key claims; further confirmation needed.
Related in Longevity
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.