Longevity
Cycloastragenol
Also known as: CAG, TA-65 active compound, Astragaloside IV metabolite
Astragalus-derived compound that may activate telomerase. Expensive and experimental telomere-focused longevity supplement.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Telomere support
- Longevity
- Immune function
How it works
- May activate telomerase
- Derived from astragalus
- Immune-supporting properties
- Expensive longevity compound
Dosage
- Typical range
- 5-25mg daily
- Timing
- Any time
- With food
- Optional
- Duration
- Long-term safety data limited
- Special populations
- Telomere/longevity focused
Forms
- Capsule
Safety
Common side effects
- Limited data, appears tolerated
Contraindications
- History of cancer (theoretical)
Evidence notes
Telomerase activation shown in vitro, human evidence limited
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Longevity
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.