Longevity
AKG (Alpha-Ketoglutarate)
Also known as: AKG, α-ketoglutaric acid, Calcium alpha-ketoglutarate, Ca-AKG
AKG is a metabolic intermediate in the citric acid cycle that may support muscle protein synthesis and ammonia detoxification. Evidence for performance and body composition benefits in humans remains preliminary and limited.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every AKG (Alpha-Ketoglutarate) product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nootropics Depot AAKG 2 | 90 A | $0.33 |
| 2 | Nutricost Pre-Workout For Women Powder | 89 A | $0.73 |
| 3 | Nutricost Pre-Workout Complex | 89 A | $0.83 |
| 4 | Nootropics Depot AAKG 2:1 Powder | 86 A- | $0.33 |
| 5 | Country Life Active B-6 50mg | 82 A- | $0.47 |
| 6 | Pure Encapsulations Growth Hormone Support | 77 B+ | $0.88 |
| 7 | Codeage Liposomal Calcium AKG | 77 B+ | $0.50 |
| 8 | Nutricost Nitric Oxide Booster | 76 B+ | $0.28 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much AKG (Alpha-Ketoglutarate) should I take?
The typical range is 300-1000mg daily. Safe in studies
When should I take AKG (Alpha-Ketoglutarate)?
Morning or pre-workout. Optional.
Which form of AKG (Alpha-Ketoglutarate) is best?
Calcium AKG — Most studied for longevity. Other forms in the catalog: AKG powder, capsule, powder, tablet.
Is AKG (Alpha-Ketoglutarate) safe?
Commonly reported: Well tolerated, GI upset rare. Serious warnings: None significant. Safe
Which AKG (Alpha-Ketoglutarate) supplement scores highest?
Nootropics Depot AAKG 2, at 90/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Longevity
- Energy production
- Bone health
- Cellular metabolism
- muscle protein synthesis
- ammonia metabolism
- exercise performance
- recovery support
How it works
- Krebs cycle intermediate
- Glutamate precursor
- May reduce biological age markers
- Bone supportive (Ca-AKG)
Dosage
- Typical range
- 300-1000mg daily
- Timing
- Morning or pre-workout
- With food
- Optional
- Duration
- Safe in studies
- Special populations
- Longevity, bone health, energy
Forms
- Calcium AKG
- AKG powder
- capsule· 70/100
- tablet· 70/100
Safety
Common side effects
- Well tolerated
- GI upset rare
Contraindications
- None established
Products containing AKG (Alpha-Ketoglutarate)
Top-scoring supplements in our catalog that list AKG (Alpha-Ketoglutarate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Promising longevity research, particularly Ca-AKG
Grade B: Some human trials support key claims; further confirmation needed.
Related in Longevity
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.