Longevity
AKG (Alpha-Ketoglutarate)
Also known as: AKG, α-ketoglutaric acid, Calcium alpha-ketoglutarate, Ca-AKG
AKG is a metabolic intermediate in the citric acid cycle that may support muscle protein synthesis and ammonia detoxification. Evidence for performance and body composition benefits in humans remains preliminary and limited.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Longevity
- Energy production
- Bone health
- Cellular metabolism
- muscle protein synthesis
- ammonia metabolism
- exercise performance
- recovery support
How it works
- Krebs cycle intermediate
- Glutamate precursor
- May reduce biological age markers
- Bone supportive (Ca-AKG)
Dosage
- Typical range
- 300-1000mg daily
- Timing
- Morning or pre-workout
- With food
- Optional
- Duration
- Safe in studies
- Special populations
- Longevity, bone health, energy
Forms
- Calcium AKG
- AKG powder
- capsule· 70/100
- powder· 70/100
- tablet· 70/100
Safety
Common side effects
- Well tolerated
- GI upset rare
Contraindications
- None established
Products containing AKG (Alpha-Ketoglutarate)
Top-scoring supplements in our catalog that list AKG (Alpha-Ketoglutarate) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Promising longevity research, particularly Ca-AKG
Grade B: Some human trials support key claims; further confirmation needed.
Related in Longevity
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.