Longevity
AKG (Alpha-Ketoglutarate)
Also known as: AKG, α-ketoglutaric acid, Calcium alpha-ketoglutarate, Ca-AKG
B
Evidence
AKG is a metabolic intermediate in the citric acid cycle that may support muscle protein synthesis and ammonia detoxification. Evidence for performance and body composition benefits in humans remains preliminary and limited.
Primary uses
- Longevity
- Energy production
- Bone health
- Cellular metabolism
- muscle protein synthesis
- ammonia metabolism
- exercise performance
- recovery support
How it works
- Krebs cycle intermediate
- Glutamate precursor
- May reduce biological age markers
- Bone supportive (Ca-AKG)
Dosage
- Typical range
- 300-1000mg daily
- Timing
- Morning or pre-workout
- With food
- Optional
- Duration
- Safe in studies
- Special populations
- Longevity, bone health, energy
Forms
- Calcium AKG
- AKG powder
- capsule· 70/100
- powder· 70/100
- tablet· 70/100
Safety
Common side effects
- Well tolerated
- GI upset rare
Contraindications
- None established
Evidence notes
Promising longevity research, particularly Ca-AKG
Grade B: Some human trials support key claims; further confirmation needed.
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