What the reviews found
Supplements for Memory & Cognition
9 where systematic reviews concluded a benefit, 1 with mixed findings, 5 where they concluded no effect. Every line quotes the review and links it, so you can read the sentence yourself.
Reviews found a benefit
Systematic reviews concluded these improve an outcome tied to memory & cognition, and none concluded no effect.
- 3 reviews citedTop-scored productThorne Super EPA92Benefitcognitive decline/dementia risk(as Eicosapentaenoic Acid)
“Dietary intake or long-term supplementation of omega-3 fatty acids may help reduce risk of AD or cognitive decline.” PMID 37028557
Benefitdementia and cognitive decline risk(as Docosahexaenoic Acid)“dietary intake of omega-3 fatty acids could lower risk of all-cause dementia or cognitive decline by ∼20%, especially for docosahexaenoic acid (DHA) intake (relative risk [RR]: 0.82, I2 = 63.6%, P = 0.001)” PMID 37028557
Benefitcognitive decline(as Omega-3 DHA)“The CDR scale showed reduced progression of cognitive decline among patients with n-3-PUFA supplemental interventions, with no differences between different n-3-PUFA supplements.” PMID 38924283
- 3 reviews citedTop-scored productNutricost Bacopa Monnieri92Benefitmemory
“Bacopa monnieri improves language, learning and memory.” PMID 34978226
Benefitmemory free recall“There is some evidence to suggest that Bacopa improves memory free recall with evidence for enhancement in other cognitive abilities currently lacking perhaps due to inconsistent measures employed by studies across these cognitive domains.” PMID 22747190
- 2 reviews citedTop-scored productBulkSupplements Blueberry Extract Capsules87Benefitepisodic memory
“blueberry intake showed a statistically significant improvement in episodic memory.” PMID 40856863
Benefitlanguage memory“Blueberry intake was also associated with improved language memory in MCI patients” PMID 40856863
- B Complex5 reviews citedBenefitcognitive decline and dementia risk
“This meta-analysis suggests that B vitamin supplementation is associated with slowing of cognitive decline, especially in populations who received early intervention and intervention of long duration” PMID 34432056 · 2 reviews
- 2 reviews citedTop-scored productNutricost Caffeine Capsules92Benefitcognitive function (attention and executive function)
“Caffeine enhances attention and executive functions.” PMID 34978226
- 2 reviews citedTop-scored productJarrow Formulas Citicoline (CDP Choline)96Benefitcognitive function in healthy individuals
“It also enhances cognitive functions among healthy individuals and improves prognosis after stroke” PMID 33053828
- 1 review citedTop-scored productThorne Creatine98Benefitmemory
“Creatine supplementation enhanced measures of memory performance in healthy individuals, especially in older adults (66-76 years).” PMID 35984306
- 1 review citedTop-scored productBluebonnet Nutrition VITAMIN B1 100 mg82Benefitcognitive function in alcohol use disorder(as Thiamine)
“Additionally, studies have demonstrated that thiamine supplementation in AUD patients, even in the absence of thiamine deficit, leads to improvements in cognitive function.” PMID 39818490
- 1 review citedTop-scored productPure Encapsulations Lutein/Zeaxanthin93Benefitcognitive function
“This systematic review showed a direct relationship among cognitive functions, macular pigment and the intake of lutein and zeaxanthin.” PMID 35752349
Mixed: a benefit on one measure, no effect on another
- 4 reviews citedTop-scored productNutricost CDP Choline Capsules95No effectcognitive function in mental disorders
“current evidence does not support citicoline or PS-containing compounds as effective cognitive enhancers in mental disorders” PMID 42538853
Benefitcognitive impairment“The inclusion of a highly effective drug in the specialized medical care system will ensure the availability of cognitive impairment treatment programs and improve patients' quality of life.” PMID 41362980
Benefitcognitive function and stroke prognosis“It also enhances cognitive functions among healthy individuals and improves prognosis after stroke.” PMID 33053828
Reviews found no effect
Reviews studied these for an outcome tied to memory & cognition and concluded they made no difference.
- 1 review citedTop-scored productPure Encapsulations DHEA 5 mg92No effectcognitive performance
“Overall, this systematic review does not support a beneficial effect of DHEA therapy on cognitive performance in postmenopausal women.” PMID 37788418
- Lignans1 review citedNo effectcognitive function
“Anthocyanidins, phenolic acids, and lignans did not significantly affect cognitive outcomes (MMSE or ADCS-Cog)” PMID 41524705
- 1 review citedTop-scored productThorne Phosphatidylserine95No effectcognitive performance
“current evidence does not support citicoline or PS-containing compounds as effective cognitive enhancers in mental disorders” PMID 42538853
- 2 reviews citedTop-scored productNootropics Depot Taurine Capsules93No effectneurocognition
“Supplementation also improved blood pressure and exercise capacity, though no significant effects on neurocognition were observed.” PMID 41803812
No effectcognitive function“Taurine, administered alone or in combination with exercise training, did not exhibit significant effects in cognitive scores.” PMID 40320621
- 2 reviews citedTop-scored productThorne Vitamin B1296No effectcognitive function
“we found no evidence for an effect of B12 alone or B complex supplementation on any subdomain of cognitive function outcomes” PMID 33809274 · 2 reviews
Not enough to say
Reviews of Ashwagandha, Beetroot, Ginkgo Biloba, Isoflavones, Phospholipids, Resveratrol, Rhodiola, Valerian, Vitamin B6, Vitamin C could not conclude either way on memory & cognition.
How this page is built
Each finding is the conclusion a set of systematic reviews reached on one outcome — whether an ingredient helped, made no difference, or could not be judged — with a sentence quoted from one review, checked to appear in its PubMed abstract. It records the direction, not the size, of an effect. Reviews run in populations such as people with cancer, pregnancy, surgery or children are left out, because applying them to a general reader would mislead. Evidence last refreshed September 2026. Abstracts courtesy of the U.S. National Library of Medicine (PubMed). The full report explains how the conclusions were read and checked.
Other goals
Educational only. A review finding a benefit on average does not mean a supplement will help you, or that it is safe alongside your medication. If you are treated for memory & cognition, talk to your clinician before adding anything.