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Hormone Support

DHEA (Dehydroepiandrosterone)

Also known as: Dehydroepiandrosterone, DHEA-S (sulfated form), Prasterone, DHEA (Female Fertility)

B
Evidence

DHEA is an endogenous adrenal hormone and precursor to testosterone and estrogen, with declining levels in aging. Supplementation aims to restore youthful hormone levels and support energy, mood, and sexual function.

Primary uses

  • Diminished ovarian reserve
  • IVF support
  • Egg quality
  • Ovarian aging
  • Energy and stamina
  • Mood and cognitive function
  • Sexual function
  • Bone health support
  • Body composition
  • Age-related decline mitigation

How it works

  • Testosterone and estrogen precursor
  • Immune system modulation
  • Mitochondrial energy support
  • Neurosteroid signaling

Dosage

Typical range
25-50 mg daily (some use up to 100 mg; higher doses increase side effect risk)
Timing
Morning, with breakfast
With food
Take with fat-containing food for absorption
Duration
Effects typically apparent within 2-4 weeks; most long-term studies used 6-12 months. Hormone levels should be monitored periodically.
Special populations
Women may use lower doses (10-25 mg); avoid in pregnancy and lactation; use with caution in hormone-sensitive conditions

Forms

  • Micronized capsules
  • Compounded
  • Capsule· 70/100
  • Tablet· 70/100
  • Micronized powder· 70/100

Safety

Common side effects

  • Acne or oily skin
  • Mood changes or irritability
  • Hair loss or excess hair growth
  • Sleep disturbance
  • Mild headache

Contraindications

  • Hormone-sensitive breast cancer
  • Prostate cancer or elevated PSA without medical clearance
  • Polycystic ovary syndrome without medical supervision
  • Pregnancy and lactation
  • Uncontrolled hypertension

Evidence notes

Moderate-to-good human evidence for specific outcomes (sexual function, mood, bone density) with mixed results. Well-studied compared to most hormonal supplements, but individual responses vary significantly.

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.