Hormone Support
Pregnenolone
Also known as: Mother hormone, PREG, Steroid precursor
Precursor hormone supporting overall steroid hormone production including cortisol.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Pregnenolone product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Nootropics Depot Eurycomax Capsules | 86 A- | $2.17 |
| 2 | Double Wood Pregnenolone Supplement | 83 A- | $0.33 |
| 3 | Life Extension Pregnenolone | 83 A- | $0.24 |
| 4 | Nootropics Depot Cistamax Capsules | 82 A- | $0.50 |
| 5 | Life Extension Cognitex Elite Pregnenolone | 81 A- | $1.48 |
| 6 | Vital Nutrients Pregnenolone 10mg | 76 B+ | $0.25 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Pregnenolone should I take?
The typical range is 5-50mg daily. Cycle recommended
When should I take Pregnenolone?
Morning. With fat.
Which form of Pregnenolone is best?
Capsule — Standard. Other forms in the catalog: Micronized.
Is Pregnenolone safe?
Commonly reported: Irritability, Acne, Hair changes. Serious warnings: Unpredictable hormone conversion. Hormone metabolism
Which Pregnenolone supplement scores highest?
Nootropics Depot Eurycomax Capsules, at 86/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Hormone support
- Cognitive function
- Mood
- Memory
- HPA axis support
- Hormone balance
- Cognition
How it works
- Precursor to all steroid hormones
- Neurosteroid with brain effects
- Modulates GABA and NMDA
Dosage
- Typical range
- 5-50mg daily
- Timing
- Morning
- With food
- With fat
- Duration
- Cycle recommended
- Special populations
- Age-related decline
Forms
- Capsule
- Micronized
Safety
Common side effects
- Irritability
- Acne
- Hair changes
Contraindications
- Hormone-sensitive cancers
Products containing Pregnenolone
Top-scoring supplements in our catalog that list Pregnenolone on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Limited clinical evidence
Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.
Related in Hormone Support
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.