Hormone Support

Pregnenolone

Also known as: Mother hormone, PREG, Steroid precursor

Evidence

Precursor hormone supporting overall steroid hormone production including cortisol.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Hormone support
Cognitive function
Mood
Memory
HPA axis support
Hormone balance
Cognition

How it works

Precursor to all steroid hormones
Neurosteroid with brain effects
Modulates GABA and NMDA

Dosage

Typical range: 5-50mg daily
Timing: Morning
With food: With fat
Duration: Cycle recommended
Special populations: Age-related decline

Forms

Capsule
Micronized

Safety

Common side effects

Irritability
Acne
Hair changes

Contraindications

Hormone-sensitive cancers

Products containing Pregnenolone

Top-scoring supplements in our catalog that list Pregnenolone on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Evidence notes

Limited clinical evidence

Grade C: Mostly observational or small trials; mechanism is plausible but unproven at scale.

Related in Hormone Support

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.