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Hormone Support

Bovine Adrenal Cortex (Supranal)

Also known as: adrenal cortex extract, adrenal glandular, bovine adrenal glandular, adrenal tissue extract

D
Evidence

Bovine adrenal cortex is a glandular extract derived from cattle adrenal glands, traditionally used to support adrenal function and stress resilience. Evidence for efficacy is limited and primarily anecdotal; clinical research is sparse.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Adrenal support
  • Stress management
  • Energy and fatigue
  • Hormonal balance support

How it works

  • Provides endogenous hormones and cofactors (cortisol, DHEA, chromaffin cell compounds) that may support adrenal axis function
  • Potential nutritional support via micronutrients present in adrenal tissue

Dosage

Typical range
300–500 mg daily
Timing
Morning or with meals
With food
May be taken with food to minimize digestive upset
Duration
No established optimal duration; typically used ongoing for chronic support
Special populations
Not established for pregnancy/lactation or pediatric use; autoimmune individuals should consult a practitioner

Forms

  • Capsule· 70/100
  • Tablet· 70/100
  • Powder· 70/100

Safety

Common side effects

  • Mild GI upset
  • Nausea
  • Headache (rare)

Contraindications

  • Autoimmune adrenal disorders (Addison's disease)
  • Cushing's syndrome or excess cortisol states
  • Pregnancy and lactation (insufficient safety data)
  • Bovine tissue allergy or sensitivity

Products containing Bovine Adrenal Cortex (Supranal)

Top-scoring supplements in our catalog that list Bovine Adrenal Cortex (Supranal) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne
Adrenal Cortex
78
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Evidence notes

Very limited peer-reviewed clinical evidence. No high-quality RCTs demonstrating efficacy for adrenal fatigue or stress support. Historical use and practitioner anecdotes predominate; theoretical benefit based on tissue content rather than empirical validation.

Grade D: Primarily pre-clinical or anecdotal; human efficacy not established.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.