What the reviews found
Supplements for Liver Health
5 where systematic reviews concluded a benefit, 1 with mixed findings, 7 where they concluded no effect, and 1 where harm was reported. Every line quotes the review and links it, so you can read the sentence yourself.
Reviews found a benefit
Systematic reviews concluded these improve an outcome tied to liver health, and none concluded no effect.
- Benefitliver enzymes
“Carotenoid supplementation might be beneficial in reducing liver enzymes, especially in non-healthy participants and in those with a BMI ≥ 25 kg/m2.” PMID 41437050
Benefitliver disease risk“lower serum concentrations of α-carotene, β-carotene, and lycopene were associated with a higher risk of liver disease.” PMID 39229651
- Anthocyanins2 reviews citedBenefitliver injury markers
“improvements in liver health, including decreased serum ALT and AST, reduced steatosis, and lower histological damage” PMID 41396784
- Benefitliver enzymes
“Artichoke supplementation elicited significant reductions in liver enzymes, especially among patients with non-alcoholic fatty liver disease.” PMID 34383355
- Benefitliver enzymes
“This meta-analysis showed that chicory supplementation may exert potential hepatoprotective effects in patients with NAFLD.” PMID 37202083
- Benefitliver enzymes
“alkaline phosphatase (ALP) (WMD= -14.84, 95% CI: -27.81, -1.87), and aspartate aminotransferase (AST) (WMD= -4.99, 95% CI: -7.26, -2.71).” PMID 41652544
Mixed: a benefit on one measure, no effect on another
- Benefitliver damage/histology in nafld
“Silymarin can regulate energy metabolism, attenuate liver damage, and improve liver histology in NAFLD patients.” PMID 38579127
No effectliver enzymes (alt/ast)“Silymarin minimally reduced, but without clinical relevance, the serum levels of ALT and AST.” PMID 28785154 · 2 reviews
Reviews found no effect
Reviews studied these for an outcome tied to liver health and concluded they made no difference.
- No effectnafld markers (liver enzymes, lipids, glycemic indices, obesity)
“ALA supplementation did not improve liver enzymes, lipid profiles, glycemic indices, adipocytokines, and obesity measures in patients with NAFLD.” PMID 41917882
- Top-scored productThorne Berberine3 reviews cited96No effectliver enzymes (alt/ast)
“Berberine administration had no significant effect on ALT and AST levels.” PMID 32690176
- Top-scored productNutricost TMG Capsules1 review cited92No effectliver enzymes
“Moreover, our analysis indicated that betaine supplementation did not affect serum concentrations of triglyceride (TG), high-density lipoprotein (HDL), fasting blood glucose (FBG), C-reactive protein (CRP), liver enzymes [alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT)], and blood pressure.” PMID 33764214
- Top-scored productPure Encapsulations DHEA 5 mg1 review cited92No effectliver enzymes
“DHEA supplementation decreased circulating cortisol but did not alter adiponectin, leptin, AST, and ALT levels.” PMID 34342920
- No effectliver disease risk
“no significant difference was observed between serum β-cryptoxanthin (SMD = 0.02, 95% CI (-0.41, 0.45), P = 0.92) and lutein/zeaxanthin (SMD = 0.62, 95% CI (-1.20, 2.45), P = 0.502).” PMID 39229651
- Piperine1 review citedNo effectliver aminotransferase levels
“adding piperine to curcumin did not benefit aminotransferase levels in NAFLD patients.” PMID 38965866
- No effectliver disease risk
“no significant difference was observed between serum β-cryptoxanthin (SMD = 0.02, 95% CI (-0.41, 0.45), P = 0.92) and lutein/zeaxanthin (SMD = 0.62, 95% CI (-1.20, 2.45), P = 0.502).” PMID 39229651
Harm reported
- Harm reportedkidney and liver function(as Whey Protein)
“The majority of the papers associated the damaging effect with the chronic and abusive use of whey protein, with the kidneys and liver being the main organs affected.” PMID 32702243
Not enough to say
Reviews of Algal Oil, Catechins, L-Methionine, Nicotinamide Mononucleotide, Pomegranate, Resveratrol, Rice Bran, Whey protein could not conclude either way on liver health.
How this page is built
Each finding is the conclusion a set of systematic reviews reached on one outcome — whether an ingredient helped, made no difference, or could not be judged — with a sentence quoted from one review, checked to appear in its PubMed abstract. It records the direction, not the size, of an effect. Reviews run in populations such as people with cancer, pregnancy, surgery or children are left out, because applying them to a general reader would mislead. Evidence last refreshed September 2026. Abstracts courtesy of the U.S. National Library of Medicine (PubMed).
Other goals
Educational only. A review finding a benefit on average does not mean a supplement will help you, or that it is safe alongside your medication. If you are treated for liver health, talk to your clinician before adding anything.