Botanical

Milk Thistle (Silymarin)

Also known as: Silybum marianum, Silymarin, Silybin, Milk Thistle Extract (Silybum marianum)

Evidence

Milk thistle extract contains silymarin, a flavonoid complex traditionally used to support liver health and function. Clinical evidence suggests modest benefits for liver support, though results remain mixed across studies.

Primary uses

Liver protection
Liver regeneration
Toxin exposure
Alcohol support
Liver health support
Hepatic function
Antioxidant support
Liver detoxification

How it works

Protects liver cell membranes
Stimulates protein synthesis for regeneration
Antioxidant in liver tissue
May help with insulin sensitivity

Dosage

Typical range: 200-400mg standardized extract 2-3x daily
Timing: With meals
With food: Yes, enhances absorption
Duration: Long-term use safe and appropriate
Special populations: Those with liver concerns, alcohol users, medication users

Forms

Standardized extract 70-80% silymarin
Phytosome (silybin-PC)
Seed extract
Powder· 70/100
Capsule· 70/100
Tablet· 70/100
Liquid extract· 70/100
Standardized extract· 70/100

Safety

Common side effects

Rare: mild GI upset
Allergic reactions (ragweed family)

Contraindications

Ragweed/daisy allergy

Evidence notes

Strong evidence for liver protection

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.