What the reviews found
Supplements for Heart & Arteries
12 where systematic reviews concluded a benefit, 2 with mixed findings, 4 where they concluded no effect. Every line quotes the review and links it, so you can read the sentence yourself.
Reviews found a benefit
Systematic reviews concluded these improve an outcome tied to heart & arteries, and none concluded no effect.
- Olive Oil2 reviews citedBenefitcardiovascular disease risk
“which highlighted the association between VOO consumption (including EVOO) and a reduced risk of cardiovascular disease.” PMID 40507112
Benefitendothelial function“Available evidence suggests that a MED diet supplemented with olive oil compared with the LFD significantly improves inflammation and serum endothelial function in adults.” PMID 39530776
- B Complex2 reviews citedBenefitmajor adverse cardiovascular events
“itamin combinations were associated with significant reductions in stroke (RR 0.79, 95% CI 0.68-0.93) and MACE (RR 0.80, 95% CI 0.69-0.92).” PMID 41830012
- Benefitvascular endothelial function
“This systematic review/meta-analysis with limited and moderate certainty evidence suggests that the continuous intake of lycopene-containing products may have beneficial effects on vascular endothelial function in healthy adults.” PMID 42588128 · 2 reviews
- Omega 6 Fatty Acids2 reviews citedBenefitcoronary heart disease risk
“LA levels were inversely associated with total CHD risk (RR: 0.85, 95% CI: 0.71, 1.00), but not AA.” PMID 35380474
- Top-scored productThorne Vitamin B122 reviews cited96Benefitmajor adverse cardiovascular events (mace)
“itamin combinations were associated with significant reductions in stroke (RR 0.79, 95% CI 0.68-0.93) and MACE (RR 0.80, 95% CI 0.69-0.92).” PMID 41830012
- Benefitcardiovascular risk factors
“Overall, the results demonstrated that CoQ10 supplementation may improve several cardiovascular risk factors in patients with prediabetes and T2DM.” PMID 42642774
- Top-scored productThorne 5-MTHF 5 mg1 review cited96Benefitendothelial function(as Folic Acid)
“folic acid (MD: 3.36; CoE: Low)” PMID 42277453
- Hydroxytyrosol1 review citedBenefitcardiovascular disease risk
“which highlighted the association between VOO consumption (including EVOO) and a reduced risk of cardiovascular disease.” PMID 40507112
- Benefitcardiovascular function and vo2 max
“l-arginine supplements may improve cardiovascular function, ventilation, the serum level of lactate, and maximal oxygen consumption (VO2 Max) of football players.” PMID 39915258
- Top-scored productThorne Magnesium Glycinate1 review cited96Benefitendothelial function
“The most substantial improvements in FMD were observed with magnesium (MD: 8.17; CoE: High)” PMID 42277453
- Oleuropein1 review citedBenefitcardiovascular disease risk
“highlighted the association between VOO consumption (including EVOO) and a reduced risk of cardiovascular disease” PMID 40507112
- Benefitcardiovascular disease risk
“This study demonstrates that spirulina supplementation effectively reduces the risk of CVD in adults by improving glucose homeostasis, dyslipidemia, blood pressure, anthropometric indexes, and inflammation.” PMID 40953712
Mixed: a benefit on one measure, no effect on another
- Benefitcardiovascular events and mortality(as Fish Oil)
“higher n-3 PUFA exposure through fish oil supplementation or higher baseline levels was associated with fewer cardiovascular events and all-cause mortality” PMID 41851014
No effectcardiovascular events and atrial fibrillation risk(as Docosahexaenoic Acid)“this analysis indicates no broad benefit in reducing MACE or AF risk with combined moderate-dose EPA + DHA in heterogeneous post-event populations” PMID 42144851
Benefitcoronary heart disease mortality and events(as Docosahexaenoic Acid)“Moderate- and low-certainty evidence suggests that increasing LCn3 slightly reduces risk of coronary heart disease mortality and events, and reduces serum triglycerides (evidence mainly from supplement trials).” PMID 32114706
2 more review findings — see Omega-3 (fish oil, EPA, DHA).
- Benefitendothelial function (flow-mediated dilation)(as Cholecalciferol)
“These findings suggest that vitamin D supplementation may be a beneficial intervention for improving endothelial function, particularly in populations with low FMD.” PMID 39986938
No effectarterial stiffness (augmentation index)(as Cholecalciferol)“The effects on PWV were modest, while AIx remained unaffected.” PMID 39986938
Reviews found no effect
Reviews studied these for an outcome tied to heart & arteries and concluded they made no difference.
- Top-scored productThorne Grape Seed Extract1 review cited92No effectflow-mediated dilation
“had no significant effects on FMD (WMD: 1.02%, 95% CI: -0.62 to 2.66, I2 = 92.0%) and SBP (WMD: -3.55 mmHg, 95% CI: -7.59 to 0.49, I2 = 97.4%).” PMID 34798267
- No effectendothelial dysfunction markers
“However, the effects of pomegranate supplementation on CRP, E-selectin, ICAM, VCAM or MDA were not significant in this meta-analysis.” PMID 32147056
- Vitamin K12 reviews citedNo effectcardiovascular risk factors
“We demonstrated that supplementation with vitamin K has no effect on anthropometrics indexes, CRP, glucose metabolism, and lipid profile factors except HOMA-IR.” PMID 38282652
No effectcoronary heart disease“No associations were found between vitamin K1 intake and coronary heart disease (CHD) (4 cohorts) or stroke (2 cohorts) in multivariate analyses.” PMID 20850029
- Top-scored productJarrow Formulas MK-7 - 90mcg3 reviews cited95No effectlipid profile and other cardiovascular risk factors
“We demonstrated that supplementation with vitamin K has no effect on anthropometrics indexes, CRP, glucose metabolism, and lipid profile factors except HOMA-IR.” PMID 38282652
Not enough to say
Reviews of Allicin, Alpha Lipoic Acid, Blueberry, Copper, L-Carnitine, Oleic Acid, Resveratrol, Vitamin B1 (thiamine), Vitamin B6, Watermelon could not conclude either way on heart & arteries.
How this page is built
Each finding is the conclusion a set of systematic reviews reached on one outcome — whether an ingredient helped, made no difference, or could not be judged — with a sentence quoted from one review, checked to appear in its PubMed abstract. It records the direction, not the size, of an effect. Reviews run in populations such as people with cancer, pregnancy, surgery or children are left out, because applying them to a general reader would mislead. Evidence last refreshed September 2026. Abstracts courtesy of the U.S. National Library of Medicine (PubMed).
Other goals
Educational only. A review finding a benefit on average does not mean a supplement will help you, or that it is safe alongside your medication. If you are treated for heart & arteries, talk to your clinician before adding anything.