Cardiovascular
Grape Seed Extract
Also known as: OPC, Proanthocyanidins
Rich in OPCs for vascular health. Strengthens capillaries and supports circulation.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Grape Seed Extract product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne Berberine | 96 A | $1.47 |
| 2 | Thorne Grape Seed Extract | 92 A | $0.90 |
| 3 | Nutricost Grape Seed Extract (400 MG) (240 CAP) | 88 A | $0.09 |
| 4 | Physician's Choice Eye Health Supplement | 87 A | $0.80 |
| 5 | NOW Foods Extra Strength Alpha Lipoic Acid | 87 A | $0.29 |
| 6 | Thorne MediClear-SGS™ - Vanilla | 86 A- | $2.10 |
| 7 | NOW Foods Grape Seed | 83 A- | $0.13 |
| 8 | NutraBio Immune | 83 A- | $1.33 |
| 9 | Pure Encapsulations PhytoBalance II | 82 A- | $0.47 |
| 10 | NOW Foods Clinical Strength Ocu Support | 81 A- | $0.73 |
| 11 | Vital Nutrients Grape Seed Extract 100mg | 81 A- | $0.80 |
| 12 | NOW Foods True Focus | 80 A- | $0.31 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Grape Seed Extract should I take?
The typical range is 100-300mg standardized extract. Ongoing
When should I take Grape Seed Extract?
Any time. Optional.
Which form of Grape Seed Extract is best?
Standardized extract — OPC content specified.
Is Grape Seed Extract safe?
Commonly reported: Rare. Serious warnings: None. Safe
Which Grape Seed Extract supplement scores highest?
Thorne Berberine, at 96/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Vascular health
- Circulation
- Antioxidant
- Blood pressure
What systematic reviews concluded
Outcomes that systematic reviews of Grape Seed Extract reached a verdict on: 5 with a benefit, 1 with no effect, 2 unclear. Each is quoted from a review and linked to it on PubMed. How these were read.
Reviews found a benefit (5)
“GSE supplementation significantly reduced DBP (WMD: -2.20 mmHg, 95% CI: -3.79 to -0.60, I2 = 88.8%) and HR (WMD: -1.25 bpm, 95% CI: -2.32 to -0.19, I2 = 59.5%) but had no significant effects on FMD” PMID 34798267
“It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses.” PMID 34107109
“intervention with bilberry and blackcurrant extract, and to some extent grape seed extract, significantly lowered total and low density lipoprotein (LDL) cholesterol levels after four weeks.” PMID 34067538
“grape seed extract and other grape products, such as grape extract, juice and raisins, decreased CRP levels significantly.” PMID 32921322
“Caries prevention by grape seed extract may be unique compared with fluoride, and is linked to grape seed extract's bacteriostatic and collagen crosslinking properties.” PMID 31760860
Reviews found no effect (1)
“had no significant effects on FMD (WMD: 1.02%, 95% CI: -0.62 to 2.66, I2 = 92.0%) and SBP (WMD: -3.55 mmHg, 95% CI: -7.59 to 0.49, I2 = 97.4%).” PMID 34798267
Not enough to say: systolic blood pressure; inflammation.
How it works
- Strengthens capillaries
- Potent antioxidant
- Supports endothelial function
Dosage
- Typical range
- 100-300mg standardized extract
- Timing
- Any time
- With food
- Optional
- Duration
- Ongoing
- Special populations
- Circulation, venous insufficiency, eye health
Forms
- Standardized extract
Safety
Common side effects
- Rare
Contraindications
- None
Products containing Grape Seed Extract
Top-scoring supplements in our catalog that list Grape Seed Extract on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
OPC-rich vascular support
Grade B: Some human trials support key claims; further confirmation needed.
Related in Cardiovascular
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.