Cardiovascular
Grape Seed Extract
Also known as: OPC, Proanthocyanidins
Rich in OPCs for vascular health. Strengthens capillaries and supports circulation.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Vascular health
- Circulation
- Antioxidant
- Blood pressure
How it works
- Strengthens capillaries
- Potent antioxidant
- Supports endothelial function
Dosage
- Typical range
- 100-300mg standardized extract
- Timing
- Any time
- With food
- Optional
- Duration
- Ongoing
- Special populations
- Circulation, venous insufficiency, eye health
Forms
- Standardized extract
Safety
Common side effects
- Rare
Contraindications
- None
Products containing Grape Seed Extract
Top-scoring supplements in our catalog that list Grape Seed Extract on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
OPC-rich vascular support
Grade B: Some human trials support key claims; further confirmation needed.
Related in Cardiovascular
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.