Cardiovascular
Horse Chestnut Extract
Also known as: Aesculus hippocastanum, Aescin, Horse Chestnut Extract (Aesculus hippocastanum), Aesculus hippocastanum seed extract
Horse chestnut extract, standardized to escin, is traditionally used to support venous circulation and reduce symptoms of chronic venous insufficiency. Multiple clinical trials support its efficacy for reducing leg swelling, heaviness, and pain related to venous dysfunction.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Venous insufficiency
- Leg swelling
- Varicose veins
- Circulation
- Venous insufficiency support
- Leg swelling and edema reduction
- Circulatory health
- Leg heaviness and discomfort
How it works
- Strengthens vein walls
- Reduces capillary permeability
- Anti-inflammatory
Dosage
- Typical range
- 300mg extract with 50-100mg aescin daily
- Timing
- Divided doses
- With food
- Yes
- Duration
- Ongoing for vein support
- Special populations
- Venous insufficiency, heavy legs, standing jobs
Forms
- Standardized extract
- Powder extract· 70/100
- Standardized extract capsules· 70/100
- Topical gel· 70/100
Safety
Common side effects
- GI upset
- Itching
Contraindications
- Kidney disease
- Liver disease
Products containing Horse Chestnut Extract
Top-scoring supplements in our catalog that list Horse Chestnut Extract on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Strong evidence for venous insufficiency
Grade A: Multiple well-designed human trials support the main claims.
Related in Cardiovascular
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.