5-MTHF 5 mg
Scored by the Formulate Research Team · Last reviewed May 2026
Overview: Thorne 5-MTHF 5 mg
Support heart health, fetal development, nervous system, and mood with 5-MTHF* 5-MTHF is a bioactive, methylated form of folate, an essential B vitamin that supports heart, brain, blood, and bone health and is suitable for individuals with MTFHR gene mutations.*
Score Breakdown
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Ingredients per Serving
| Ingredient | Amount |
|---|---|
| FolateL-5-MTHF | 16.6 mg DFE |
Certifications & Testing
Other Ingredients
Hypromellose (derived from cellulose) capsule, Leucine, Microcrystalline Cellulose, Silicon Dioxide
Recommended Use
Take 1 capsule one to two times daily or as recommended by your health-care practitioner.
Warnings
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY If pregnant, consult your health-care practitioner before using this product. INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic ac
Frequently Asked Questions
What is Thorne 5-MTHF 5 mg's Formulate score?
Thorne 5-MTHF 5 mg scores 98 out of 100 (grade A) on Formulate's ingredient-level rubric, which weighs evidence quality, dose accuracy, bioavailability, transparency, safety, and manufacturing practices.
Is Thorne 5-MTHF 5 mg worth it?
Thorne 5-MTHF 5 mg scores 98/100 (grade A). That puts it in Formulate's top tier: its ingredient doses, forms, and label transparency hold up against the clinical evidence, and it carries credible third-party testing. Formulate grades every product with the same automated rubric, so the score reflects the formula — not marketing or sponsorships.
What's in Thorne 5-MTHF 5 mg?
Each serving contains Folate (16.6 mg DFE). Serving size: 1 Capsule. 60 servings per container.
How do I take 5-mthf 5 mg?
Take 1 capsule one to two times daily or as recommended by your health-care practitioner.
Who makes 5-MTHF 5 mg?
5-MTHF 5 mg is made by Thorne. See Formulate's full grade and product lineup for Thorne on its brand page.
Is Thorne 5-MTHF 5 mg third-party tested?
Thorne lists the following certifications and testing for this product: NSF Certified, Gluten Free, Dairy Free, Soy Free, Thorne Verified, Natural Flavors, Natural Colors, GMP Certified.
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Disclosure. Formulate may earn a commission from purchases made through links on this page. Commissions never influence scores — every product is graded by the same automated rubric. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.