Vitamin
Methylfolate
Also known as: Folate, L-methylfolate, 5-MTHF, Metafolin
Active form of folate for those with MTHFR variants. Critical for methylation and mood.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Methylfolate product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne 5-MTHF 5 mg | 96 A | $1.13 |
| 2 | Thorne Craving and Stress Support | 93 A | $1.33 |
| 3 | Thorne Methyl-Guard® | 93 A | $0.93 |
| 4 | Thorne Methyl-Guard Plus | 91 A | $2.07 |
| 5 | Thorne 5-MTHF 1 mg | 90 A | $0.40 |
| 6 | Complement ForHer Hormone Balance and Longevity Multivitamin for Women | 89 A | $0.67 |
| 7 | Nutricost Pre-Workout For Women Powder | 89 A | $0.73 |
| 8 | Nutricost Pre-Workout Complex | 89 A | $0.83 |
| 9 | Garden of Life Vitamin Code Raw B-Complex | 89 A | $0.50 |
| 10 | Thorne Advanced Nutrients | 88 A | $2.40 |
| 11 | Thorne Basic Nutrients 2/Day | 88 A | $0.60 |
| 12 | Thorne Basic Prenatal | 88 A | $1.23 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Methylfolate should I take?
The typical range is 400-800mcg or up to 15mg for depression. Daily essential
When should I take Methylfolate?
Morning. Either.
Which form of Methylfolate is best?
L-methylfolate — Active form.
Is Methylfolate safe?
Commonly reported: Irritability, Insomnia, Anxiety (overmethylating). Serious warnings: May mask B12 deficiency. No concerns
Which Methylfolate supplement scores highest?
Thorne 5-MTHF 5 mg, at 96/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Daily target & upper limit
400 mcg / day · UL 1000 mcgMethylfolate has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:
Methylfolate dosage reference →Primary uses
- Mood support
- Methylation
- Pregnancy
- Cardiovascular
How it works
- Active folate form
- Essential for serotonin synthesis
- Methylation cycle
Dosage
- Typical range
- 400-800mcg or up to 15mg for depression
- Timing
- Morning
- With food
- Either
- Duration
- Daily essential
- Special populations
- MTHFR, depression, pregnancy
Forms
- L-methylfolate
Safety
Common side effects
- Irritability
- Insomnia
- Anxiety (overmethylating)
Contraindications
- None, but monitor methylation
Products containing Methylfolate
Top-scoring supplements in our catalog that list Methylfolate on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Known interactions
Evidence notes
Essential nutrient with clear mood connection
Grade A: Multiple well-designed human trials support the main claims.
Related in Vitamin
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Methylfolate fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.