Vitamin

Methylfolate

Also known as: Folate, L-methylfolate, 5-MTHF, Metafolin

Evidence

Active form of folate for those with MTHFR variants. Critical for methylation and mood.

Find the best Methylfolate supplements — free

See Methylfolate products scored on dose & form, then track your intake in the app.

Open app →

Daily target & upper limit

400 mcg / day · UL 1000 mcg

Methylfolate has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

Methylfolate dosage reference →

Primary uses

Mood support
Methylation
Pregnancy
Cardiovascular

How it works

Active folate form
Essential for serotonin synthesis
Methylation cycle

Dosage

Typical range: 400-800mcg or up to 15mg for depression
Timing: Morning
With food: Either
Duration: Daily essential
Special populations: MTHFR, depression, pregnancy

Forms

L-methylfolate

Safety

Common side effects

Irritability
Insomnia
Anxiety (overmethylating)

Contraindications

None, but monitor methylation

Products containing Methylfolate

Top-scoring supplements in our catalog that list Methylfolate on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne

5-MTHF 5 mg

Thorne

Craving and Stress Support

Known interactions

Synergywith vitamin b12
B12 and folate work together in methylation

Evidence notes

Essential nutrient with clear mood connection

Grade A: Multiple well-designed human trials support the main claims.

Related in Vitamin

Check a full stack

Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.

Open the checker

Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.