Vitamin

Methylfolate

Also known as: Folate, L-methylfolate, 5-MTHF, Metafolin

Evidence

Active form of folate for those with MTHFR variants. Critical for methylation and mood.

Primary uses

Mood support
Methylation
Pregnancy
Cardiovascular

How it works

Active folate form
Essential for serotonin synthesis
Methylation cycle

Dosage

Typical range: 400-800mcg or up to 15mg for depression
Timing: Morning
With food: Either
Duration: Daily essential
Special populations: MTHFR, depression, pregnancy

Forms

L-methylfolate

Safety

Common side effects

Irritability
Insomnia
Anxiety (overmethylating)

Contraindications

None, but monitor methylation

Known interactions

Synergywith vitamin b12
B12 and folate work together in methylation

Evidence notes

Essential nutrient with clear mood connection

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.