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Vitamin

Vitamin B6

Also known as: Pyridoxine, Pyridoxal, P5P, Pyridoxal-5-phosphate

A
Evidence

An essential B-vitamin cofactor for neurotransmitter synthesis, homocysteine metabolism, and sleep-wake regulation. Pyridoxal-5-phosphate is the active, bioavailable form that directly participates in enzymatic reactions.

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Daily target & upper limit

1.7 mg / day · UL 100 mg

Vitamin B6 has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

Vitamin B6 dosage reference →

Primary uses

  • Mood support
  • PMS relief
  • Neurotransmitter synthesis
  • Hormone balance
  • HPA axis support
  • Pregnancy nausea
  • Morning sickness
  • Nausea prevention
  • Protein metabolism
  • Immune function
  • Homocysteine metabolism
  • Sleep support

How it works

  • Cofactor for 100+ enzymes
  • Amino acid metabolism
  • Serotonin/dopamine synthesis
  • Hemoglobin synthesis

Dosage

Typical range
10-50mg daily
Timing
Morning
With food
Optional
Duration
Long-term safe at moderate doses
Special populations
Higher needs in pregnancy

Forms

  • Pyridoxine HCl
  • P5P
  • Diclegis/Diclectin
  • Pyridoxal-5-phosphate· 70/100
  • pyridoxal phosphate· 70/100

Safety

Common side effects

  • Well tolerated

Contraindications

  • None at normal doses

Products containing Vitamin B6

Top-scoring supplements in our catalog that list Vitamin B6 on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne
Craving and Stress Support
96
Thorne
Methyl-Guard®
96
Thorne
MediClear-SGS™ - Vanilla
95
Thorne
Methyl-Guard Plus®
95
See all products →

Known interactions

Evidence notes

Essential vitamin with well-established functions

Grade A: Multiple well-designed human trials support the main claims.

Cited research for Vitamin B6

Clinical studies referenced across Formulate guides that mention vitamin b6. Each links to the full study page with PubMed source + the guides that cite it.

Related in Vitamin

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.