Vitamin
Vitamin B6
Also known as: Pyridoxine, Pyridoxal, P5P, Pyridoxal-5-phosphate
A
Evidence
An essential B-vitamin cofactor for neurotransmitter synthesis, homocysteine metabolism, and sleep-wake regulation. Pyridoxal-5-phosphate is the active, bioavailable form that directly participates in enzymatic reactions.
Primary uses
- Mood support
- PMS relief
- Neurotransmitter synthesis
- Hormone balance
- HPA axis support
- Pregnancy nausea
- Morning sickness
- Nausea prevention
- Protein metabolism
- Immune function
- Homocysteine metabolism
- Sleep support
How it works
- Cofactor for 100+ enzymes
- Amino acid metabolism
- Serotonin/dopamine synthesis
- Hemoglobin synthesis
Dosage
- Typical range
- 10-50mg daily
- Timing
- Morning
- With food
- Optional
- Duration
- Long-term safe at moderate doses
- Special populations
- Higher needs in pregnancy
Forms
- Pyridoxine HCl
- P5P
- Diclegis/Diclectin
- Pyridoxal-5-phosphate· 70/100
- pyridoxal phosphate· 70/100
Safety
Common side effects
- Well tolerated
Contraindications
- None at normal doses
Known interactions
Evidence notes
Essential vitamin with well-established functions
Grade A: Multiple well-designed human trials support the main claims.
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