Skip to main content
Thorne Methyl-Guard Plus

Methyl-Guard Plus

92Score
Grade A · capsule · 30 servings · $62.00

Methyl-Guard Plus scores 92/100 (A grade). Strengths: 4 Grade A, 1 Grade B ingredients.

B-ComplexHeart HealthMethylation

Score Breakdown

Formulate scores every product across six weighted dimensions. Each dimension is graded independently — hover or tap to see what drove each component.

Evidence Qualityweight 25%
97/ 100
Dose Accuracyweight 20%
90/ 100
Bioavailabilityweight 20%
92/ 100
Transparencyweight 10%
100/ 100
Safetyweight 10%
94/ 100
Manufacturingweight 10%
82/ 100
Valueweight 5%
40/ 100

Ingredients per Serving

IngredientAmount
Betaine Anhydrous (Trimethylglycine)1.8 g
Vitamin B12 (as Methylcobalamin)3 mg
Riboflavin (as Riboflavin 5'-Phosphate Sodium)90 mg
Vitamin B6 (as Pyridoxal 5'-Phosphate)45 mg
Folate (3 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt)5 mg

Certifications & Testing

Gluten FreeSoy FreeDairy FreeNatural FlavorsNatural ColorsMade in USAThorne VerifiedGMP Certified

Other Ingredients

Calcium Citrate, Calcium Laurate, Hypromellose (derived from cellulose) capsule

Recommended Use

Take 1-3 capsules daily or as recommended by your health-care practitioner.

Warnings

ALLERGY WARNING: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY: If pregnant, consult your health-care practitioner before using this product. INTERACTIONS: 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplast

Frequently Asked Questions

What is Thorne Methyl-Guard Plus's Formulate score?

Thorne Methyl-Guard Plus scores 92 out of 100 (grade A) on Formulate's ingredient-level rubric, which weighs evidence quality, dose accuracy, bioavailability, transparency, safety, and manufacturing practices.

What's in Thorne Methyl-Guard Plus?

Each serving contains Betaine Anhydrous (Trimethylglycine) (1.8 g), Vitamin B12 (as Methylcobalamin) (3 mg), Riboflavin (as Riboflavin 5'-Phosphate Sodium) (90 mg), Vitamin B6 (as Pyridoxal 5'-Phosphate) (45 mg), and more. Serving size: Three Capsules. 30 servings per container.

How do I take methyl-guard plus?

Take 1-3 capsules daily or as recommended by your health-care practitioner.

Is Thorne Methyl-Guard Plus third-party tested?

Thorne lists the following certifications and testing for this product: Gluten Free, Soy Free, Dairy Free, Natural Flavors, Natural Colors, Made in USA, Thorne Verified, GMP Certified.

Related Supplements

Track methyl-guard plus in your stack

The Formulate desktop app lets you build a personalized supplement stack, flag dose overlaps and interactions, and keep every product scored against the latest evidence.

Disclosure. Formulate may earn a commission from purchases made through links on this page. Commissions never influence scores — every product is graded by the same automated rubric. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.