Methyl-Guard Plus
Scored by the Formulate Research Team · Last reviewed July 2026
Overview: Thorne Methyl-Guard Plus
Support cellular energy production, heart health, brain function, and mood with nutrients that optimize methylation* Methyl-Guard Plus provides superior methyl donors – trimethylglycine, 5-MTHF, and methylcobalamin – combined with bioactive vitamins B2 and B6 in a powerhouse formula for whole-body methylation support.*
Score Breakdown
Formulate scores every product across six weighted dimensions. Each dimension is graded independently — hover or tap to see what drove each component.
Ingredients per Serving
| Ingredient | Amount |
|---|---|
| Betaine AnhydrousTrimethylglycine16 systematic reviews · 88 randomised trials | 1.8 g |
| Vitamin B12Methylcobalamin141 systematic reviews · 337 randomised trials | 3 mg |
| RiboflavinRiboflavin 5'-Phosphate Sodium9 systematic reviews · 14 randomised trials | 90 mg |
| Vitamin B6Pyridoxal 5'-Phosphate62 systematic reviews · 142 randomised trials | 45 mg |
| Folate3 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt249 systematic reviews · 697 randomised trials | 5 mg |
Certifications & Testing
Other Ingredients
Calcium Citrate, Calcium Laurate, Hypromellose (derived from cellulose) capsule
Recommended Use
Take 1-3 capsules daily or as recommended by your health-care practitioner.
Warnings
ALLERGY WARNING: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY: If pregnant, consult your health-care practitioner before using this product. INTERACTIONS: 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplast
Frequently Asked Questions
What is Thorne Methyl-Guard Plus's Formulate score?
Thorne Methyl-Guard Plus scores 91 out of 100 (grade A) on Formulate's ingredient-level rubric, which weighs evidence quality, dose accuracy, bioavailability, transparency, safety, and manufacturing practices.
Is Thorne Methyl-Guard Plus worth it?
Thorne Methyl-Guard Plus scores 91/100 (grade A). That puts it in Formulate's top tier: its ingredient doses, forms, and label transparency hold up against the clinical evidence, and it carries credible third-party testing. Formulate grades every product with the same automated rubric, so the score reflects the formula — not marketing or sponsorships.
What's in Thorne Methyl-Guard Plus?
Each serving contains Betaine Anhydrous (1.8 g), Vitamin B12 (3 mg), Riboflavin (90 mg), Vitamin B6 (45 mg), and more. Serving size: Three Capsules. 30 servings per container.
How do I take methyl-guard plus?
Take 1-3 capsules daily or as recommended by your health-care practitioner.
Who makes Methyl-Guard Plus?
Methyl-Guard Plus is made by Thorne. See Formulate's full grade and product lineup for Thorne on its brand page.
Is Thorne Methyl-Guard Plus third-party tested?
Thorne lists the following certifications and testing for this product: Gluten Free, Soy Free, Dairy Free, Derived From Natural Flavors, Derived From Natural Colors, Made in USA, Thorne Verified, GMP.
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Disclosure. Formulate may earn a commission from purchases made through links on this page. Commissions never influence scores — every product is graded by the same automated rubric. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.