
Methyl-Guard Plus
Methyl-Guard Plus scores 92/100 (A grade). Strengths: 4 Grade A, 1 Grade B ingredients.
Score Breakdown
Formulate scores every product across six weighted dimensions. Each dimension is graded independently — hover or tap to see what drove each component.
Ingredients per Serving
| Ingredient | Amount |
|---|---|
| Betaine Anhydrous (Trimethylglycine) | 1.8 g |
| Vitamin B12 (as Methylcobalamin) | 3 mg |
| Riboflavin (as Riboflavin 5'-Phosphate Sodium) | 90 mg |
| Vitamin B6 (as Pyridoxal 5'-Phosphate) | 45 mg |
| Folate (3 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) | 5 mg |
Certifications & Testing
Other Ingredients
Calcium Citrate, Calcium Laurate, Hypromellose (derived from cellulose) capsule
Recommended Use
Take 1-3 capsules daily or as recommended by your health-care practitioner.
Warnings
ALLERGY WARNING: This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY: If pregnant, consult your health-care practitioner before using this product. INTERACTIONS: 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplast
Frequently Asked Questions
What is Thorne Methyl-Guard Plus's Formulate score?
Thorne Methyl-Guard Plus scores 92 out of 100 (grade A) on Formulate's ingredient-level rubric, which weighs evidence quality, dose accuracy, bioavailability, transparency, safety, and manufacturing practices.
What's in Thorne Methyl-Guard Plus?
Each serving contains Betaine Anhydrous (Trimethylglycine) (1.8 g), Vitamin B12 (as Methylcobalamin) (3 mg), Riboflavin (as Riboflavin 5'-Phosphate Sodium) (90 mg), Vitamin B6 (as Pyridoxal 5'-Phosphate) (45 mg), and more. Serving size: Three Capsules. 30 servings per container.
How do I take methyl-guard plus?
Take 1-3 capsules daily or as recommended by your health-care practitioner.
Is Thorne Methyl-Guard Plus third-party tested?
Thorne lists the following certifications and testing for this product: Gluten Free, Soy Free, Dairy Free, Natural Flavors, Natural Colors, Made in USA, Thorne Verified, GMP Certified.
Related Supplements
Track methyl-guard plus in your stack
The Formulate desktop app lets you build a personalized supplement stack, flag dose overlaps and interactions, and keep every product scored against the latest evidence.
Disclosure. Formulate may earn a commission from purchases made through links on this page. Commissions never influence scores — every product is graded by the same automated rubric. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.