Methyl-Guard®
Scored by the Formulate Research Team · Last reviewed July 2026
Overview: Thorne Methyl-Guard®
Supports methylation for healthy heart, blood vessels, brain, and bones* Methyl-Guard contains betaine, 5-MTHF, methyl-B12, and P5P to support healthy methylation for cardiovascular, cognitive, and bone health.* Methylation helps maintain healthy homocysteine levels.*
Score Breakdown
Formulate scores every product across six weighted dimensions. Each dimension is graded independently — hover or tap to see what drove each component.
Ingredients per Serving
| Ingredient | Amount |
|---|---|
| Betaine AnhydrousTrimethylglycine16 systematic reviews · 88 randomised trials | 3.6 g |
| Vitamin B12Methylcobalamin141 systematic reviews · 337 randomised trials | 2.4 mg |
| Vitamin B6Pyridoxal 5'-Phosphate62 systematic reviews · 142 randomised trials | 40.8 mg |
| FolateL-5-MTHF249 systematic reviews · 697 randomised trials | 4 mg DFE |
Certifications & Testing
Other Ingredients
Calcium (Citrate), Calcium Laurate, Hypromellose Capsule, Silicon Dioxide
Recommended Use
Take 3 capsules two times daily or as recommended by your health-care practitioner.
Warnings
ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY If pregnant, consult your health-care practitioner before using this product. INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic ac
Frequently Asked Questions
What is Thorne Methyl-Guard®'s Formulate score?
Thorne Methyl-Guard® scores 93 out of 100 (grade A) on Formulate's ingredient-level rubric, which weighs evidence quality, dose accuracy, bioavailability, transparency, safety, and manufacturing practices.
Is Thorne Methyl-Guard® worth it?
Thorne Methyl-Guard® scores 93/100 (grade A). That puts it in Formulate's top tier: its ingredient doses, forms, and label transparency hold up against the clinical evidence, and it carries credible third-party testing. Formulate grades every product with the same automated rubric, so the score reflects the formula — not marketing or sponsorships.
What's in Thorne Methyl-Guard®?
Each serving contains Betaine Anhydrous (3.6 g), Vitamin B12 (2.4 mg), Vitamin B6 (40.8 mg), Folate (4 mg DFE). Serving size: 3 Capsules. 60 servings per container.
How do I take methyl-guard®?
Take 3 capsules two times daily or as recommended by your health-care practitioner.
Who makes Methyl-Guard®?
Methyl-Guard® is made by Thorne. See Formulate's full grade and product lineup for Thorne on its brand page.
Is Thorne Methyl-Guard® third-party tested?
Thorne lists the following certifications and testing for this product: NSF Certified, Gluten Free, Dairy Free, Soy Free, Thorne Verified, Natural Flavors, Natural Colors, GMP Certified.
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Disclosure. Formulate may earn a commission from purchases made through links on this page. Commissions never influence scores — every product is graded by the same automated rubric. This page is for educational purposes only and does not replace advice from a qualified healthcare provider.