Nootropic

Phosphatidylserine (PS)

Also known as: PS, Serine phospholipid, Phosphatidylserine, Soy/sunflower phosphatidylserine

Evidence

Phospholipid that may blunt excessive cortisol response, particularly useful for overtraining.

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Primary uses

Memory
Focus
Stress/cortisol
Brain cell health
Cortisol reduction
Cognitive support
Exercise recovery
Stress
Overtraining

How it works

Critical membrane component
Supports neurotransmitter release
May blunt cortisol response

Dosage

Typical range: 100-300 mg daily
Timing: With meals
With food: Yes
Duration: Benefits develop over weeks
Special populations: Cognitive decline, athletes

Forms

Soy-derived
Sunflower-derived
Capsule
Softgel
Softgels

Safety

Common side effects

Mild GI upset
Insomnia

Contraindications

None

Products containing Phosphatidylserine (PS)

Top-scoring supplements in our catalog that list Phosphatidylserine (PS) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne

Phosphatidylserine

Nootropics Depot

Smart PS™ Phosphatidylserine Softgels

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Evidence notes

FDA-qualified health claim for cognitive function

Grade A: Multiple well-designed human trials support the main claims.

Cited research for Phosphatidylserine (PS)

Clinical studies referenced across Formulate guides that mention phosphatidylserine (ps). Each links to the full study page with PubMed source + the guides that cite it.

Related in Nootropic

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.