Nootropic
Phosphatidylserine (PS)
Also known as: PS, Serine phospholipid, Phosphatidylserine, Soy/sunflower phosphatidylserine
Phospholipid that may blunt excessive cortisol response, particularly useful for overtraining.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Memory
- Focus
- Stress/cortisol
- Brain cell health
- Cortisol reduction
- Cognitive support
- Exercise recovery
- Stress
- Overtraining
How it works
- Critical membrane component
- Supports neurotransmitter release
- May blunt cortisol response
Dosage
- Typical range
- 100-300 mg daily
- Timing
- With meals
- With food
- Yes
- Duration
- Benefits develop over weeks
- Special populations
- Cognitive decline, athletes
Forms
- Soy-derived
- Sunflower-derived
- Capsule
- Softgel
- Softgels
Safety
Common side effects
- Mild GI upset
- Insomnia
Contraindications
- None
Products containing Phosphatidylserine (PS)
Top-scoring supplements in our catalog that list Phosphatidylserine (PS) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
FDA-qualified health claim for cognitive function
Grade A: Multiple well-designed human trials support the main claims.
Cited research for Phosphatidylserine (PS)
Clinical studies referenced across Formulate guides that mention phosphatidylserine (ps). Each links to the full study page with PubMed source + the guides that cite it.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.