Nootropic
Phosphatidylserine (PS)
Also known as: PS, Serine phospholipid, Phosphatidylserine, Soy/sunflower phosphatidylserine
A
Evidence
Phospholipid that may blunt excessive cortisol response, particularly useful for overtraining.
Primary uses
- Memory
- Focus
- Stress/cortisol
- Brain cell health
- Cortisol reduction
- Cognitive support
- Exercise recovery
- Stress
- Overtraining
How it works
- Critical membrane component
- Supports neurotransmitter release
- May blunt cortisol response
Dosage
- Typical range
- 100-300 mg daily
- Timing
- With meals
- With food
- Yes
- Duration
- Benefits develop over weeks
- Special populations
- Cognitive decline, athletes
Forms
- Soy-derived
- Sunflower-derived
- Capsule
- Softgel
- Softgels
Safety
Common side effects
- Mild GI upset
- Insomnia
Contraindications
- None
Evidence notes
FDA-qualified health claim for cognitive function
Grade A: Multiple well-designed human trials support the main claims.
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