Nootropic

Coffee Fruit Extract

Also known as: CognatiQ, NeuroFactor, Coffeeberry, Coffee Berry

Evidence

Extract from the fruit surrounding coffee beans. Shown to significantly increase BDNF (brain-derived neurotrophic factor) levels, supporting neuroplasticity and cognitive function.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

BDNF support
Cognitive function
Neuroprotection
Brain health

How it works

Increases BDNF (brain-derived neurotrophic factor)
Supports neuroplasticity
Polyphenol antioxidant activity
May support neuron growth and survival

Dosage

Typical range: 100-200 mg daily
Timing: Morning or early afternoon
With food: Optional
Duration: Effects may build over weeks
Special populations: Cognitive support focus

Forms

Capsule
Powder

Safety

Common side effects

Mild stimulation (contains some caffeine)

Contraindications

Caffeine sensitivity

Products containing Coffee Fruit Extract

Top-scoring supplements in our catalog that list Coffee Fruit Extract on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne

Brain Factors

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Evidence notes

Multiple studies showing BDNF increase; cognitive benefits emerging

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.