Nootropic
Lion's Mane Mycelium
Also known as: Hericium erinaceus, Yamabushitake, Bearded tooth mushroom, Hou Tou Gu
Lion's Mane mushroom mycelium contains bioactive compounds (hericenones and erinacines) studied for potential cognitive and neurological support. A growing body of research, primarily in Asia, suggests benefits for brain health, though larger Western trials are needed.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Lion's Mane Mycelium product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Integrative Therapeutics ProThrivers Wellness Brain | 83 A- | $1.07 |
| 2 | Terra Origin Healthy Mushroom Capsules | 83 A- | $1.00 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Lion's Mane Mycelium should I take?
The typical range is 1,000-3,000 mg daily (mycelium form). Consistent daily use for 4-8 weeks may be needed for cognitive effects
When should I take Lion's Mane Mycelium?
With meals. Recommended for optimal absorption.
Which form of Lion's Mane Mycelium is best?
Mycelium on rice biomass. Other forms in the catalog: Fruiting body extract, Capsule.
Is Lion's Mane Mycelium safe?
Commonly reported: Rare: mild digestive upset, Rare: allergic reactions in mushroom-sensitive individuals.
Which Lion's Mane Mycelium supplement scores highest?
Integrative Therapeutics ProThrivers Wellness Brain, at 83/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Cognitive support
- Nerve growth factor (NGF) support
- Immune support
How it works
- Hericenone and erinacine compounds that may stimulate NGF production
- Polysaccharide immune modulation
- Potential neuroprotection
Dosage
- Typical range
- 1,000-3,000 mg daily (mycelium form)
- Timing
- With meals
- With food
- Recommended for optimal absorption
- Duration
- Consistent daily use for 4-8 weeks may be needed for cognitive effects
- Special populations
- Safe for most adults; pregnant/nursing should consult provider
Forms
- Mycelium on rice biomass· 70/100
- Fruiting body extract· 70/100
- Capsule· 70/100
Safety
Common side effects
- Rare: mild digestive upset
- Rare: allergic reactions in mushroom-sensitive individuals
Contraindications
- Mushroom allergies
- Bleeding disorders (theoretical)
Products containing Lion's Mane Mycelium
Top-scoring supplements in our catalog that list Lion's Mane Mycelium on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Multiple animal studies and several preliminary human trials show promise for cognitive and neuroprotective effects. Evidence is stronger than most medicinal mushrooms but still developing. Some human studies show cognitive benefits in older adults with mild cognitive impairment.
Grade B: Some human trials support key claims; further confirmation needed.
Cited research for Lion's Mane Mycelium
Clinical studies referenced across Formulate guides that mention lion's mane mycelium. Each links to the full study page with PubMed source + the guides that cite it.
- Nagano M, Shimizu K, Kondo R, et al. (2010)Biomedical Research
Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake
- Mori K, Inatomi S, Ouchi K, et al. (2009)Phytotherapy Research
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.