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Nootropic

Acetyl-L-Carnitine (ALCAR)

Also known as: ALC, Acetyl L-Carnitine HCl, ALCAR, Acetyl-L-Carnitine

B
Evidence

Acetyl L-Carnitine is a form of carnitine that crosses the blood-brain barrier and supports mitochondrial energy production and acetylcholine synthesis. It has shown modest benefits for cognitive function and energy metabolism in some studies, with stronger evidence in elderly populations and carnitine-deficient states.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

1000 mg / day

Acetyl-L-Carnitine (ALCAR) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

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Primary uses

  • Brain energy
  • Memory
  • Neuroprotection
  • Mood
  • Cognitive support
  • Energy and fatigue
  • Brain health and neuroprotection
  • Age-related cognitive decline

How it works

  • Crosses BBB
  • Acetyl donor for acetylcholine
  • Supports mitochondrial function in brain

Dosage

Typical range
500-2000 mg daily
Timing
Morning (mildly stimulating)
With food
Optional
Duration
Safe long-term
Special populations
Cognitive aging, depression

Forms

  • Capsules
  • Powder
  • HCl salt (hydrochloride)· 70/100
  • Tablets· 70/100

Safety

Common side effects

  • GI upset
  • Fishy odor
  • Insomnia if late

Contraindications

  • Seizure disorders (caution)

Products containing Acetyl-L-Carnitine (ALCAR)

Top-scoring supplements in our catalog that list Acetyl-L-Carnitine (ALCAR) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Nootropics Depot
Acetyl L-Carnitine HCL (ALCAR) Capsules
94
Nutricost
Acetyl L-Carnitine Powder
94
Nootropics Depot
Acetyl L-Carnitine ALCAR Powder
94
Thorne
Acetyl-L-Carnitine
92
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Evidence notes

Brain-penetrating carnitine

Grade B: Some human trials support key claims; further confirmation needed.

Cited research for Acetyl-L-Carnitine (ALCAR)

Clinical studies referenced across Formulate guides that mention acetyl-l-carnitine (alcar). Each links to the full study page with PubMed source + the guides that cite it.

Acetyl-L-Carnitine (ALCAR) compared head-to-head

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.