Nootropic
Huperzine A
Also known as: Huperzia serrata extract
Potent acetylcholinesterase inhibitor from Chinese club moss. Increases acetylcholine levels for enhanced memory and focus.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Memory
- Focus
- Neuroprotection
- Learning
How it works
- Inhibits acetylcholinesterase
- Increases synaptic acetylcholine
- NMDA receptor modulation
Dosage
- Typical range
- 50-200 mcg daily
- Timing
- Cycling recommended (5 on, 2 off)
- With food
- Optional
- Duration
- Cycle to prevent tolerance
- Special populations
- Cognitive enhancement, students
Forms
- Capsules
Safety
Common side effects
- Nausea
- Diarrhea
- Vivid dreams
Contraindications
- Epilepsy
- Heart conditions
- GI obstruction
Evidence notes
Potent cholinesterase inhibitor
Grade B: Some human trials support key claims; further confirmation needed.
Related in Nootropic
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Huperzine A fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.