Nootropic

Alpha-GPC

Also known as: L-alpha glycerylphosphorylcholine, Choline alfoscerate, Alpha-glycerophosphocholine

Evidence

Highly bioavailable choline source crossing the blood-brain barrier. Supports acetylcholine and growth hormone.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

550 mg / day · UL 3500 mg

Alpha-GPC has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

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Primary uses

Choline supply
Memory
Focus
Athletic power
Power output
Mind-muscle connection
Growth hormone
Brain health
Choline source
Athletic performance

How it works

Crosses BBB efficiently
Acetylcholine precursor
May boost growth hormone

Dosage

Typical range: 300-600 mg daily
Timing: Morning or pre-workout
With food: Optional
Duration: Acute effects
Special populations: Athletes, cognitive support

Forms

Capsules
Powder
Capsule

Safety

Common side effects

Headache
GI upset
Fishy body odor

Contraindications

None

Evidence notes

Superior choline delivery to brain

Grade B: Some human trials support key claims; further confirmation needed.

Alpha-GPC compared head-to-head

Cholinergic Nootropics
Alpha-GPC vs Acetyl-L-Carnitine (ALCAR)

Related in Nootropic

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.