Antioxidant
Ergothioneine
Also known as: Ergo, L-ergothioneine, EGT
Longevity amino acid with unique cellular uptake via dedicated transporter. Potent antioxidant concentrated in mitochondria, potential longevity compound.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Longevity
- Antioxidant
- Mitochondrial protection
- Neuroprotection
How it works
- Dedicated cellular transporter (OCTN1)
- Concentrates in mitochondria
- Potent antioxidant
- Levels decline with age
Dosage
- Typical range
- 5-25mg daily
- Timing
- Any time
- With food
- Optional
- Duration
- Safe long-term
- Special populations
- Longevity-focused, antioxidant support
Forms
- Capsule
Safety
Common side effects
- Very well tolerated
Contraindications
- None established
Evidence notes
Emerging longevity research, dedicated transporter suggests importance
Grade B: Some human trials support key claims; further confirmation needed.
Related in Antioxidant
Check a full stack
Formulate's free interaction checker lets you paste in any combination of supplements and medications at once — every pairing flags severity, timing, and cited evidence.
Open the checkerWhere does Ergothioneine fit in your stack?
Answer two questions and get a stack graded on research — every ingredient scored on the evidence behind it, not the marketing.
Build my stack2 questions · free · no account needed to start
Also on iPhone — get the free app
Evidence-based supplement guides, no spam
We send a short digest when new guides drop — nothing else. No affiliate pushes, no sponsored content, unsubscribe anytime.
Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.