Heart Health

Niacin (Vitamin B3)

Also known as: Nicotinic acid, Vitamin B3 (lipid), Niacin, Vitamin B3

Evidence

Niacinamide is a water-soluble B vitamin essential for energy metabolism, DNA repair, and cellular signaling. It supports mental clarity and sustained energy production without the flushing effect associated with nicotinic acid.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

16 mg / day · UL 35 mg

Niacin (Vitamin B3) has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

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Primary uses

HDL increase
Triglycerides
LDL reduction
Lp(a)
energy production
mental clarity
NAD+ synthesis
cognitive function

How it works

Increases HDL
Lowers triglycerides and LDL
May reduce Lp(a)

Dosage

Typical range: 500-2000mg daily (titrate up slowly)
Timing: With food, evening
With food: Yes (reduces flushing)
Duration: Ongoing, monitor liver
Special populations: Low HDL, high triglycerides, Lp(a)

Forms

Immediate release
Extended release
No-flush (inositol hexanicotinate)
niacinamide· 70/100
nicotinamide· 70/100

Safety

Common side effects

Flushing (common)
GI upset
Itching
Glucose elevation

Contraindications

Active liver disease
Peptic ulcer
Gout (relative)

Products containing Niacin (Vitamin B3)

Top-scoring supplements in our catalog that list Niacin (Vitamin B3) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne

Craving and Stress Support

Basic Nutrients 2/Day

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Evidence notes

Effective for lipids, causes flushing

Grade A: Multiple well-designed human trials support the main claims.

Related in Heart Health

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.