Heart Health

Niacin (Vitamin B3)

Also known as: Nicotinic acid, Vitamin B3 (lipid), Niacin, Vitamin B3

Evidence

Niacinamide is a water-soluble B vitamin essential for energy metabolism, DNA repair, and cellular signaling. It supports mental clarity and sustained energy production without the flushing effect associated with nicotinic acid.

Primary uses

HDL increase
Triglycerides
LDL reduction
Lp(a)
energy production
mental clarity
NAD+ synthesis
cognitive function

How it works

Increases HDL
Lowers triglycerides and LDL
May reduce Lp(a)

Dosage

Typical range: 500-2000mg daily (titrate up slowly)
Timing: With food, evening
With food: Yes (reduces flushing)
Duration: Ongoing, monitor liver
Special populations: Low HDL, high triglycerides, Lp(a)

Forms

Immediate release
Extended release
No-flush (inositol hexanicotinate)
niacinamide· 70/100
nicotinamide· 70/100

Safety

Common side effects

Flushing (common)
GI upset
Itching
Glucose elevation

Contraindications

Active liver disease
Peptic ulcer
Gout (relative)

Evidence notes

Effective for lipids, causes flushing

Grade A: Multiple well-designed human trials support the main claims.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider.