Performance
Pycnogenol (Pine Bark Extract)
Also known as: French maritime pine bark, Pinus pinaster
Antioxidant that enhances nitric oxide production. Cardiovascular and pump support.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Primary uses
- Nitric oxide
- Cardiovascular
- Antioxidant
- Blood flow
How it works
- Increases eNOS activity
- Powerful antioxidant
- Synergistic with arginine
Dosage
- Typical range
- 50-200mg
- Timing
- With meals or pre-workout
- With food
- Yes
- Duration
- Ongoing for cardiovascular
- Special populations
- Cardiovascular support, pump
Forms
- Capsule
Safety
Common side effects
- GI upset
- Headache
- Dizziness
Contraindications
- Autoimmune conditions
Products containing Pycnogenol (Pine Bark Extract)
Top-scoring supplements in our catalog that list Pycnogenol (Pine Bark Extract) on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
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Evidence notes
Good evidence for cardiovascular and NO
Grade B: Some human trials support key claims; further confirmation needed.
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.