Performance

L-Arginine

Also known as: L-Arginine, AAKG, L-Arginine (Wound Healing), Arginine

Evidence

Direct nitric oxide precursor. Less effective orally than citrulline but still used.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Daily target & upper limit

3 g / day

L-Arginine has an established daily reference intake. See best forms, label synonyms, upper-limit warnings, and top-scoring supplements:

L-Arginine dosage reference →

Primary uses

Pump
Blood flow
Nitric oxide
Wound healing
Collagen synthesis
Surgery recovery

How it works

Direct NO precursor
Poor oral bioavailability
Arginase breaks it down

Dosage

Typical range: 3-6g
Timing: Pre-workout
With food: Either
Duration: Acute effects
Special populations: Those who respond to arginine

Forms

Powder
Capsule
Capsules

Safety

Common side effects

GI upset
Diarrhea

Contraindications

Post heart attack
Herpes (may reactivate)

Products containing L-Arginine

Top-scoring supplements in our catalog that list L-Arginine on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Evidence notes

Supports healing via NO and collagen

Grade B: Some human trials support key claims; further confirmation needed.

Cited research for L-Arginine

Clinical studies referenced across Formulate guides that mention l-arginine. Each links to the full study page with PubMed source + the guides that cite it.

Shao A, Hathcock JN (2008)Regulatory Toxicology and Pharmacology
Risk assessment for the amino acids taurine, L-glutamine and L-arginine

Related in Performance

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.