Digestive
Bromelain
Also known as: Pineapple enzyme, Bromelain (Wound Healing), Proteolytic enzyme
Pineapple-derived protease enzyme supporting protein digestion and having anti-inflammatory properties.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Bromelain product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Thorne Protein Isolate - Chocolate | 96 A | $1.47 |
| 2 | Thorne Whey Protein Isolate - Vanilla | 96 A | $1.47 |
| 3 | Thorne Phytoprofen® | 91 A | $1.37 |
| 4 | Thorne Quercetin Complex | 90 A | $0.90 |
| 5 | NutraBio Curcumin Advanced | 90 A | $1.23 |
| 6 | Thorne Joint Support Nutrients | 87 A | $1.00 |
| 7 | Pure Encapsulations Systemic Enzyme Complex | 86 A- | $1.35 |
| 8 | Pure Encapsulations Bromelain 2400 | 86 A- | $0.67 |
| 9 | Pure Encapsulations A.I. Enzymes | 85 A- | $1.28 |
| 10 | Pure Encapsulations A.I. Formula | 85 A- | $0.61 |
| 11 | NOW Foods Turmeric & Bromelain | 85 A- | $0.40 |
| 12 | Pure Encapsulations Hist Reset | 84 A- | $1.02 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Bromelain should I take?
The typical range is 500-2000 GDU daily. Safe long-term
When should I take Bromelain?
Between meals for inflammation; with meals for digestion. Depends on goal.
Which form of Bromelain is best?
Capsules — Enteric-coated for systemic. Other forms in the catalog: Tablets, Enteric-coated.
Is Bromelain safe?
Commonly reported: GI upset, Diarrhea. Serious warnings: Bleeding risk. Safe
Which Bromelain supplement scores highest?
Thorne Protein Isolate - Chocolate, at 96/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Protein digestion
- Inflammation
- Sinus support
- Injury recovery
- Swelling reduction
- Bruising
- Surgery recovery
- Anti-inflammatory
- Sinusitis
- Wound healing
What systematic reviews concluded
Outcomes that systematic reviews of Bromelain reached a verdict on: 1 with a benefit, 1 unclear. Each is quoted from a review and linked to it on PubMed. How these were read.
Reviews found a benefit (1)
“Bromelain supplementation is effective in improving glycemic and lipid indices in diabetes.” PMID 40440445
Not enough to say: inflammatory markers.
1 finding from reviews in specific patient groups (such as cancer, pregnancy or surgery) is not shown here.
How it works
- Proteolytic enzyme activity
- Anti-inflammatory effects systemic
- Fibrinolytic properties
Dosage
- Typical range
- 500-2000 GDU daily
- Timing
- Between meals for inflammation; with meals for digestion
- With food
- Depends on goal
- Duration
- Safe long-term
- Special populations
- Surgery recovery, sinusitis
Forms
- Capsules
- Tablets
- Enteric-coated
Safety
Common side effects
- GI upset
- Diarrhea
Contraindications
- Before surgery
- Bleeding disorders
Products containing Bromelain
Top-scoring supplements in our catalog that list Bromelain on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Digestive and anti-inflammatory uses
Grade B: Some human trials support key claims; further confirmation needed.
Related in Digestive
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.