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Digestive

DPP-IV Enzyme

Also known as: Dipeptidyl peptidase IV, Gluten enzyme

B
Evidence

Specialized enzyme for gluten and casein breakdown. Helps with accidental exposure, not for celiac disease.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

  • Gluten exposure
  • Casein sensitivity
  • Accidental contamination

How it works

  • Cleaves proline-rich peptides
  • Breaks down gluten and casein
  • For accidental exposure only

Dosage

Typical range
1-2 capsules with meals
Timing
Before or with meals
With food
Yes
Duration
As needed
Special populations
Gluten/casein sensitive (not celiac)

Forms

  • Capsules

Safety

Common side effects

  • None

Contraindications

  • Not a substitute for GF diet

Evidence notes

For accidental gluten exposure only

Grade B: Some human trials support key claims; further confirmation needed.

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.