Digestive
Lipase
Also known as: Fat-digesting enzyme, Pancreatic lipase, Pancrelipase
Fat-digesting enzyme for those with fat malabsorption or pancreatic insufficiency.
Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.
Every Lipase product we have scored
| # | Product | Score | Per serving |
|---|---|---|---|
| 1 | Pure Encapsulations A.I. Enzymes | 85 A- | $1.28 |
| 2 | Bluebonnet Nutrition POWER-ZYMES DIGESTIVE ENZYME | 71 B | $0.47 |
| 3 | Bluebonnet Nutrition FULL SPECTRUM OPTIMUM ENZYMES DIGESTIVE ENZYME | 67 B | $0.33 |
| 4 | Integrative Therapeutics Bio-Zyme | 63 B- | $0.43 |
Scored on dose accuracy, form, label transparency and third-party testing. Per-serving cost is list price divided by servings per container. No brand pays to be listed or ranked.
Common questions
How much Lipase should I take?
The typical range is 3000-10000 FIP units with meals. As needed
When should I take Lipase?
With fatty meals. Yes.
Which form of Lipase is best?
Capsules — With meals. Other forms in the catalog: In digestive blends.
Is Lipase safe?
Commonly reported: GI upset. Serious warnings: None at normal doses. Safe
Which Lipase supplement scores highest?
Pure Encapsulations A.I. Enzymes, at 85/100. Scored on dose accuracy, form, label transparency and third-party testing — no brand pays to be listed or ranked.
Primary uses
- Fat digestion
- Pancreatic support
- Fat malabsorption
How it works
- Breaks down triglycerides
- Essential for fat absorption
Dosage
- Typical range
- 3000-10000 FIP units with meals
- Timing
- With fatty meals
- With food
- Yes
- Duration
- As needed
- Special populations
- Pancreatic insufficiency
Forms
- Capsules
- In digestive blends
Safety
Common side effects
- GI upset
Contraindications
- Acute pancreatitis
Products containing Lipase
Top-scoring supplements in our catalog that list Lipase on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.
Evidence notes
Essential for fat digestion
Grade B: Some human trials support key claims; further confirmation needed.
Related in Digestive
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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.