Digestive

Papain

Also known as: Carica papaya enzyme, Papain (Papaya Enzyme), Papaya enzyme

Evidence

Protein-digesting enzyme from papaya. Traditional digestive aid with anti-inflammatory properties.

Last reviewed June 2026 · Evidence graded from peer-reviewed research, not editorial opinion. Educational only — not medical advice.

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Primary uses

Protein digestion
Inflammation
Digestive support

How it works

Proteolytic enzyme
Works across wide pH range
Anti-inflammatory

Dosage

Typical range: 500-1000 mg with meals
Timing: With or after meals
With food: Yes
Duration: As needed
Special populations: Protein digestion

Forms

Chewable tablets
Capsules

Safety

Common side effects

Throat irritation
GI upset

Contraindications

Latex allergy
Before surgery

Products containing Papain

Top-scoring supplements in our catalog that list Papain on the label. Each product is graded on Formulate's ingredient-level rubric — dose accuracy, form, transparency, and third-party testing.

Thorne

Protein Isolate - Chocolate

Thorne

Whey Protein Isolate - Vanilla

See all products →

Evidence notes

Traditional digestive enzyme

Grade B: Some human trials support key claims; further confirmation needed.

Related in Digestive

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Medical disclaimer. This page is educational and does not replace advice from a qualified healthcare provider. Individual needs and risks vary — consult a professional before starting, stopping, or combining supplements, especially if you are pregnant or nursing, taking medication, or managing a health condition.